Evaluation of the efficacy of ADC in vitro and in vivo
Abstract Antibody drug conjugates (ADCs) are promising complexes with therapeutic potential that aimed to the treatment of solid tumor and...
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Validation of GVHD in mouse model for preclinical efficacy screen
AACR Annual meeting 2021 Na Xu, Ya Zhang, Rou Xie, Lijun Jia, Yingying Cai, Qing Lin Oncology and Immunology Unit,...
Continue Reading Engineered cell line panel complemented with in vivo models to enable next-generation target therapy discovery...
AACR Annual meeting 2021 Authors: Zhixiang Zhang1, Feifei Fan2, Xiaohe Shi2, Xiangyang Zuo2, Qingyang Gu2, Qunsheng Ji1. 1 WuXi AppTec,...
Continue Reading Establishment of drug induced resistant tumor models enable the development of next generation anticancer therapeutics
AACR Annual meeting 2021 Ting Ni, Zhixiang Zhang, Xuzhen Tang, Hui Qi, Jingying Zhang, Ke Mao, Wenting Shi, Qingyang Gu,...
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Establishment of KRAS-G12C inhibitor induced resistant tumor models enable the development of new generation KRAS-G12C...
Activating KRAS mutations, including G12C and G12D, are detected in approximately 25% of human cancers. The most common KRAS mutation...
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Biomarker discovery Mouse clinical trial 61 PDX-derived primary cancer cell lines Drug-resistant xenograft models Combination therapy platform including radiation World...
Continue Reading Patient-Derived Xenograft (PDX) Tumor Models
One of the largest collection of Patient-Derived Xenograft (PDX) Tumor Models in Asia with gene expression/mutation profiling 1200 PDX models...
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