Knowledge Library

Bifunctional Molecules: A Diverse New Modality That Unlocks New Target Classes
Resource Type: White Paper
Resource Topic: Hit Finding Hit-to-Lead Oncology Small Molecules Target-Specific Assays Targeted Protein Degradation

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How Diversity In Therapeutic Strategies Is Expanding The Drug Discovery Toolbox
Resource Type: White Paper
Resource Topic: Antibody Drug Conjugate Oligonucleotides Oncology Rare Diseases Target Identification and Validation Targeted Protein Degradation THERAPEUTIC MODALITIES

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Quantum Mechanics for Organic Chemists: An Experimentalist Approach

Magical Power of Quantum Mechanics EBook Would you like to predict organic reaction outcomes accurately? Design synthetic sequences with higher rate of success? Would you prefer to learn and rationalize organic chemistry in a data-driven manner? Quantum Mechanics (QM) and artificial intelligence tools for chemistry are evolving at a tremendously fast pace and have proven to …Read More >
Resource Type: Ebook
Resource Topic: Discovery Chemistry in silico services Quantum Mechanics Small Molecules

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Target Discovery & Validation

Target Discovery and Validation Propelled by CRISPR and Other New Technologies Library screen platform CRISPR based AGMTM (advanced gene manipulation) platform Diversified cell bank Comprehensive functional and phenotypic assay
Resource Type: Brochure
Resource Topic: Biomarkers Cell-based Assays Cells and Protein Science Chemical Biology and Proteomics Gene Manipulation Gene Therapies Hit Finding Hit-to-Lead Lead Optimization Phenotypic Assays Screening Libraries Target Identification and Validation Target-Specific Assays

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CAR-T TCR-T

Integrated Platforms To Accelerate CAR-T/TCR-T Programs Comprehensive target validation program OXGENE based target expression system ensure high-efficiency delivery Systematic in vitro functional & safety assays in vivo efficacy studies Well-established genomic editing technology in primary immune cells
Resource Type: Brochure
Resource Topic: CAR-T Cell Cell Therapies Cell-based Assays Gene Manipulation Oncology Safety and Early Toxicity Target Identification and Validation

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Targeted Protein Degradation Platform PROTAC

PROTAC BIOLOGY & PHARMACOLOGY BINARY/TERNARY COMPLEX FORMATION Biochemical & Biophysical Assays Biochemical binding assay Cellular Assays TARGET UBIQUITINATION & DEGRADATION In vitro Assays-Target ubiquitination Target degradation assay PK/PD Animal Disease Model Evaluation PROTAC CHEMISTRY PROTAC specific virtual library design Compound synthesis Conjugation and all type of custom syntheses from milligram to kilogram scale Purification and …Read More >
Resource Type: Brochure
Resource Topic: Biochemical Assays Biomarkers Biophysical Assays Cell-based Assays Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead in vitro biology in vivo Pharmacology Lead Optimization Small Molecules Targeted Protein Degradation

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Antibody and Protein Preparation Services

Integrated Drug Discovery Platform for Antibody & Protein Preparation From Shanghai, Suzhou in China to Munich in Germany, more than 100 senior scientists are dedicated to offer an integrated and cost-effective service of polyclonal antibody and monoclonal antibody including: antigen design and preparation, anti-drug antibodies (ADA), host cell protein (HCP) antibodies, surrogate antibodies, diagnostic antibody, …Read More >
Resource Type: Brochure Latest Science
Resource Topic: Antibodies Cells and Protein Science Immunology Target Identification and Validation

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One-stop DEL services from target to hit series – DELpro

WuXi AppTec  provides a one-stop solution for DEL services from target to hit series. Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.
Resource Type: Brochure
Resource Topic: Biophysical Assays Cells and Protein Science Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead Small Molecules Target Identification and Validation

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Open Access to DEL for data sharing – DELopen

DELopen platform is dedicated to the development and application of DEL technology in drug discovery. Free access to DEL, data sharing. DELopen encourages an open, community-based approach to data sharing and exploration of the capabilities of DEL technology. We envision that DELopen will help academia benefits from the efficiency of DEL and unlock the full …Read More >
Resource Type: Brochure
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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