Biological Characterization and Development Workflows for Targeted Protein Degradation

This webinar will focus on PROTAC biology workflows, such as in vitro screening assays, in vivo testing, and optimization of DMPK properties. Topics will include the best use of biochemical assays to measure binary/ternary complex formation, cell-based assays to assess target engagement and degradation, strategies for enhancing drug delivery and formulation, and PK/PD evaluation of PROTACs in animal models.

Key Learning Objectives:

• PROTAC biology workflows, including in vitro screening assays, in vivo testing, and optimization of DMPK properties
• Strategies for enhancing drug delivery and formulation
• PK/PD evaluation of PROTACs in animal models