DEL Library Construction| Customize your own DEL
DNA-encoded library (DEL) is synthesized through combinatorial chemistry and DNA encoding. A well-designed library, combined with a reliable production process, provides drug hunters with efficient access to desired chemical spaces, laying a solid foundation for your drug discovery success.
DEL Production| Professional & One-stop
WuXi Biology provides one-stop DEL library production services. Whether starting from your own design or using our library precursors, our comprehensive and robust production capabilities guarantee the delivery of high-quality libraries tailored to your needs.
Why Choose WuXi Biology as Your DEL Partner?
1400+ Library production experience, delivering 1.1 Trillion+ DEL molecules
100+ DNA compatible reactions, empowering novel scaffold generation
104.2K+ readily available building blocks, including proprietary scaffolds from WuXi Chemistry
300K+ validation data points,effectively accelerating pre-production validation
70+ Available Library Precursors with at least 1 functional handle for rapid hit expansion & focus DEL
DEL precursors + … of Interest
pharmacophore
electrophile
E3 ligands
conservative AA sequence
= focused/SAR DEL
= covalent DEL
= PROTAC, molecular glue DEL
= peptide optimization DEL
We Produce DELs for New Molecules
- Highly Customization
- Multi-dimensional QC
Diversity DEL
- Extensive number of building blocks
- Numerous DNA compatible reactions
- Diverse scaffolds and molecular shapes covering broad chemical space
Peptide DEL
- 1400+ validated natural and unnatural amino acids ready for use
- Experience for Linear, monocyclic, bicyclic and stapled peptide DELs
- •Well-established cyclization strategies
Molecular Glue DEL
- Rational design based on POI or E3 ligands
- Multiple in-house successful case studies for reference
Covalent DEL
- A large collection of validated covalent electrophiles
- Extensive experience in building reversible and irreversible covalent DEL libraries
Bi-functional DEL
- Widely used & novel reported E3 ligands and diverse linkers available
- Various practicable DNA connection strategies
We Produce DELs for New Scenarios
- Multiple Assay Formats
- Enhanced Signal-to-noise
On-beads DEL
- For various assay formats: affinity assay, functional assay, cellar assay
- Synthesize molecules on microbeads
RNA “Zipper” DEL
- For effectively reduce the motif binding and amplify signal-to-noise
- Complete the single-stranded DNA on the DEL molecules to prevent the ssDNA binding with the target
Bi-functional DEL
- For identify low affinity fragments
- The fragment covalently attached to target by photo-crosslinking to enhance the screen signal
How do we achieve quality excellence?
- Iteratively optimized reaction protocols
- Stable storage and accurate weighing in building block management
- Rigorous validation of designed reaction routes and curated building blocks
- Multi-dimensional QC during and after library production
