DEL Library Construction| Customize your own DEL
DNA-encoded library (DEL) is synthesized through combinatorial chemistry and DNA encoding. A well-designed library, combined with a reliable production process, provides drug hunters with efficient access to desired chemical spaces, laying a solid foundation for your drug discovery success.
DEL Production| Professional & One-stop
WuXi Biology provides one-stop DEL library production services. Whether starting from your own design or using our library precursors, our comprehensive and robust production capabilities guarantee the delivery of high-quality libraries tailored to your needs.
Why Choose WuXi Biology as Your DEL Partner?
1400+ Library production experience, delivering 1.1 Trillion+ DEL molecules
100+ DNA compatible reactions, empowering novel scaffold generation
104.2K+ readily available building blocks, including proprietary scaffolds from WuXi Chemistry
300K+ validation data points,effectively accelerating pre-production validation
70+ Available Library Precursors with at least 1 functional handle for rapid hit expansion & focus DEL
DEL precursors + … of Interest
pharmacophore = focused/SAR DEL
electrophile = covalent DEL
E3 ligands = PROTAC, molecular glue DEL
conservative AA sequence = peptide optimization DEL
We Produce DELs for New Molecules
Highly Customization
Multi-dimensional QC
Diversity DEL
- Extensive number of building blocks
- Numerous DNA compatible reactions
- Diverse scaffolds and molecular shapes covering broad chemical space
Peptide DEL
- 1400+ validated natural and unnatural amino acids ready for use
- Experience for Linear, monocyclic, bicyclic and stapled peptide DELs
- •Well-established cyclization strategies
Molecular Glue DEL
- Rational design based on POI or E3 ligands
- Multiple in-house successful case studies for reference
Covalent DEL
- A large collection of validated covalent electrophiles
- Extensive experience in building reversible and irreversible covalent DEL libraries
Bi-functional DEL
- Widely used & novel reported E3 ligands and diverse linkers available
- Various practicable DNA connection strategies
We Produce DELs for New Scenarios
Multiple Assay Formats
Enhanced Signal-to-noise
On-beads DEL
- For various assay formats: affinity assay, functional assay, cellar assay
- Synthesize molecules on microbeads
RNA “Zipper” DEL
- For effectively reduce the motif binding and amplify signal-to-noise
- Complete the single-stranded DNA on the DEL molecules to prevent the ssDNA binding with the target
Bi-functional DEL
- For identify low affinity fragments
- The fragment covalently attached to target by photo-crosslinking to enhance the screen signal
How do we achieve quality excellence?
Iteratively optimized reaction protocols
Stable storage and accurate weighing in building block management
Rigorous validation of designed reaction routes and curated building blocks
Multi-dimensional QC during and after library production
