Development of Rodent Models for Diabetic Neuropathy

Diabetic neuropathy, a common complication of diabetes, affects approximately 50% of diabetic patients and can lead to a range of symptoms, including chronic pain, numbness, and loss of sensation in the extremities, particularly the feet. Animal models are crucial for understanding the mechanisms of diabetic neuropathy and developing novel treatments. However, reproducing the complexity of human diabetic neuropathy in animal models is challenging, as the pathogenesis of this disorder is not fully understood.

At the 2025 American Diabetes Association (ADA) meeting, WuXi Biology presented a poster on the development of rodent models of diabetic neuropathy, as well as the validation of these models using multiple reference agents.  The authors demonstrate that these models exhibit impaired nerve conduction and significant neuropathic pain, whereas positive control treatments effectively alleviate these complications.

Poster_ADA 2025_Diabetic Neuropathy

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