Targeting MC4R with Setmelanotide Improves Metabolic Parameters in DIO Mice

The global obesity epidemic is a significant public health concern, increasing the risk of various chronic diseases, including diabetes, cardiovascular diseases, and certain cancers, ultimately reducing overall quality of life. Approximately 1-5% of severely obese patients have been found to carry heterozygous mutations in the melanocortin-4 receptor (MC4R) gene. Targeting MC4R, which regulates appetite and energy in the brain, has become a promising approach to combating obesity.

At the 32nd European Congress on Obesity, WuXi Biology presented a poster on the efficacy of setmelanotide, an MC4R agonist, in reducing body weight and improving metabolic parameters in a diet-induced obesity (DIO) mouse model. The authors demonstrate that setmelanotide effectively reduced body weight and food intake, and improved metabolic biomarkers. These findings spotlight MC4R activation as a promising treatment strategy for obesity.

ECO 2025 Poster_Targeting MC4R with Setmelanotide Improves Metabolic Parameters in DIO Mice

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