Knowledge Library

Oncolytic Virus Platform

Oncolytic viruses (OVs) are emerging as a promising therapeutic approach for treating cancer. OVs are capable of both tumor-specific cell lysis and immune stimulation and can be optimized for enhanced tumor selectivity.  WuXi AppTec offers a comprehensive platform of OV-related services, including virus engineering and validation, immune profiling and lysis assays, tumor cell selectivity assays, …Read More >

Resource Type: Latest Science, Presentation
Resource Topic: Biochemical Assays, Cell-based Assays, Oncology, Oncolytic Viruses, Safety and Early Toxicity, Tumor Models

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WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >

Resource Type: Brochure
Resource Topic: Antibodies, Biochemical Assays, Biomarkers, Cell-based Assays, Cells and Protein Science, Central Nervous System & Pain, Hit Finding, Hit-to-Lead, in vitro biology, Lead Optimization, Phenotypic Assays, Rare Diseases, Safety and Early Toxicity, Small Molecules, Target Identification and Validation

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Discovery Newsletter November 2022

Resource Type: Latest Science, Newsletter
Resource Topic: CAR-T Cell, Cell-based Assays, Chemical Biology and Proteomics, Discovery Chemistry, DRUG DISCOVERY AND INNOVATION, in vitro biology, Oligonucleotides, Oncolytic Viruses, Safety and Early Toxicity, Small Molecules, Target Identification and Validation, Target-Specific Assays

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WuXi AppTec Oligonucleotide Biology Platform

We offer a wide range of oligonucleotide services, including: Sequence design Knockdown effect in cell lines and primary cells Splicing analysis Functional assays and assessment of off-target effects Transgenic, HDI and AAV mouse models GalNAc-ASGPR delivery system and customized assays for other delivery systems Stability and protein-protein binding assays Delivery/RISC PK in mouse, rat, and …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays, Candidate Selection, Cell-based Assays, Discovery Chemistry, Gene Therapies, Hit-to-Lead, in vivo Pharmacology, Lead Optimization, Liver Diseases, Oligonucleotides, Rare Diseases, Safety and Early Toxicity, Target-Specific Assays

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Oligonucleotide Drug Discovery

Recent years have seen a huge surge of interest in oligonucleotide therapeutics, fueled by major advances in our understanding of how to make such molecules stable, selective, and efficient as drug modalities. The field is now diverse in terms of therapeutic areas being addressed, biological processes being manipulated and delivery technologies employed. In this webinar, …Read More >

Resource Type: Webinar
Resource Topic: Biochemical Assays, Cell-based Assays, Discovery Chemistry, Hit-to-Lead, in vitro biology, in vivo Pharmacology, Lead Optimization, Oligonucleotides, Safety and Early Toxicity

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platforms.  

Resource Type: Brochure
Resource Topic: Antibodies, Antibody Drug Conjugate, Autoimmune and Inflammatory Diseases, Biochemical Assays, Biomarkers, Biophysical Assays, Candidate Selection, CAR-T Cell, Cardiovascular & Metabolic Diseases, Cell Therapies, Cell-based Assays, Cells and Protein Science, Central Nervous System & Pain, Chemical Biology and Proteomics, Dermatology, Discovery Chemistry, DNA-Encoded Library (DEL), DRUG DISCOVERY AND INNOVATION, Fragment-Based Drug Discovery, Gene Therapies, High-throughput screening (HTS), Hit Finding, Hit-to-Lead, Immunology, in silico services, in vitro biology, in vivo Pharmacology, in vivo Toxicology, Infectious Diseases, Lead Optimization, Liver Diseases, Mass Spectrometry-based Assays, Metabolic Diseases, NASH, Oligonucleotides, Oncology, Oncolytic Viruses, Ophthalmology, Phenotypic Assays, Quantum Mechanics, Rare Diseases, Respiratory Diseases, Safety and Early Toxicity, Screening Libraries, Screening Services, Small Molecules, Structural Biology, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation, TECHNOLOGY PLATFORMS, THERAPEUTIC AREAS, THERAPEUTIC MODALITIES, Tumor Models

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Early in vitro safety panel – Assays and Data Summary

In vitro Biology Services |  Early in vitro safety panel – Assays and Data Summary Functional Assays Radio ligand binding Assays

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biomarkers, in vitro biology, Lead Optimization, Safety and Early Toxicity

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Virology and Viral Vector Platforms

WuXi virology platforms: Immunology, Anti viral, Viral Vector, Oligo-nucleotide, Clinical and Immunology in vitro screening and profiling in vivo efficacy clinical virology Liver-specific viruses | Respiratory viruses | Herpes viruses | Other viruses

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biomarkers, Candidate Selection, CAR-T Cell, Cell-based Assays, Cells and Protein Science, in vivo Pharmacology, in vivo Toxicology, Infectious Diseases, Lead Optimization, Oncolytic Viruses, Phenotypic Assays, Safety and Early Toxicity

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WuXi AppTec in vitro Safety Pharmacology Profiling

Comprehensive in vitro Off-target Screening Services WuXi Discovery Biology provides in vitro Safety Pharmacology services to identify potential off-target liabilities. Three choices can be selected: WuXi Biology Mini Safety Panel “WuXi Mini 44” A primary safety panel, which is designed to identify compounds with the highest risk because it contains targets associated with the most …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays, Cell-based Assays, Lead Optimization, Safety and Early Toxicity, Target-Specific Assays

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