WuXi AppTec Oligonucleotide Biology Platform
WuXi Biology oligonucleotide capabilities
- Sequence design
- Knockdown effect incell lines and primary cells (transfection d f uptake)
- Splicing analysis
- Functional assays
- Other assays: Tm determination
- Cytotoxicity
- lmmunotoxicity
- Off-target effect
- “Humanized” mouse models
- Transgenic, HDI and AAV mouse models
- NHP models
- Short and longterm KD efficacy/ harmacology readouts
- GalNAc-ASGPR delivery system
- SPR screening
- Customized assays for other delivery systems
- in vitro stability and protein-protein binding
- Delivery/RISC PK in mouse, rat, NHP
WuXi AppTec oligonucleotide platform brochure