Knowledge Library

Jurkat Reporter Cell Lines for Immunotherapy Drug Screening

WuXi AppTec offers Jurkat reporter cell lines for immunotherapy drug screening.  Our platform includes CD8+, TCR knockout and CD16-expressing Jurkat-NFAT-Luc reporter cell lines, and validated assays (using co-cultures of Raji or A375 tumor cells) to evaluate the activity of CARs, TCRs, and bispecific antibodies.  Leverage our portfolio of reporter cell lines to accelerate your research! …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Cells and Protein Science Immunology Oncology

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PRMT5-WDR77 Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Lead Optimization Structural Biology

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PIK3alpha Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Lead Optimization Structural Biology

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NLRP3 Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Structural Biology

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KRAS Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays Biophysical Assays Cells and Protein Science Hit-to-Lead Lead Optimization Structural Biology

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KRAS-related Genetically Engineered Cell Lines and In Vivo Models

KRAS mutant proteins that drive cancer development are highly similar in sequence and structure. Direct inhibitors are most likely to bind to the catalytic domain of KRAS. However, recent studies have found that KRAS mutants can also be targeted by heterogeneous sites, to develop covalent inhibitors of KRAS mutants. The discovery of inhibitors that selectively …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Biochemical Assays Biophysical Assays Cell-based Assays Cells and Protein Science Hit Finding Hit-to-Lead Lead Optimization Oncology Small Molecules Tumor Models

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WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >

Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Central Nervous System & Pain Hit Finding Hit-to-Lead in vitro biology Lead Optimization Phenotypic Assays Rare Diseases Safety and Early Toxicity Small Molecules Target Identification and Validation

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OncoWuXi Newsletter November 2022

Resource Type: Newsletter
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biomarkers Cell-based Assays Cells and Protein Science Hit-to-Lead Lead Optimization Oncology

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How Does It Work? | Protein Based Vaccines

When a new pathogen invades, it’s a race against time for your immune system to stop it from multiplying out of control. This week, we explore Protein Based Vaccines as part of our “How Does It Work?” series. Fortunately, #vaccines give your immune system a head start against dangerous pathogens. A protein-based vaccine, like this …Read More >

Resource Type: Video
Resource Topic: Cells and Protein Science Infectious Diseases Target Identification and Validation

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