Knowledge Library

WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >

Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Central Nervous System & Pain Hit Finding Hit-to-Lead in vitro biology Lead Optimization Phenotypic Assays Rare Diseases Safety and Early Toxicity Small Molecules Target Identification and Validation

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OncoWuXi Newsletter November 2022

Resource Type: Latest Science Newsletter
Resource Topic: Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Cell-based Assays Cells and Protein Science Oncology

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How Does It Work? | Protein Based Vaccines

When a new pathogen invades, it’s a race against time for your immune system to stop it from multiplying out of control. This week, we explore Protein Based Vaccines as part of our “How Does It Work?” series. Fortunately, #vaccines give your immune system a head start against dangerous pathogens. A protein-based vaccine, like this …Read More >

Resource Type: Video
Resource Topic: Cells and Protein Science Infectious Diseases Target Identification and Validation

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How Does It Work? | Peptibodies

#Research has explored the ways to extend the half-life of peptide drugs. One innovative way to achieve this is by fusing #therapeutic peptides to the Fc region of an antibody to create what is known as a peptibody. When the peptibody is naturally taken up by cells it binds to an Fc (antibody) receptor within …Read More >

Resource Type: Video
Resource Topic: Antibodies Cells and Protein Science Oncology Target-Specific Assays

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PD-1 Blockade Protein in 4th Generation Armored CAR-T Cells Enhances Cytotoxicity Effect with in vitro Re-challenge System

Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that express a surface receptor to recognize tumor-associated antigens (TAA). CAR-T cell therapy have demonstrated remarkable success with hematological malignancies. However, limited headway has been made towards solid tumor, due to various challenges, including recognition of tumor-specific antigen trafficking and penetration, localization and survival within …Read More >

Resource Type: Latest Science Poster
Resource Topic: Antibodies Biomarkers CAR-T Cell Cell Therapies Cell-based Assays Cells and Protein Science Oncology Target Identification and Validation

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond

Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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The critical platforms of PROTAC validation

In recent years, proteolysis targeting chimeric (PROTAC) technology has become an effective endogenous protein degradation tool in drug discovery. As a class of heterobifunctional small molecules, PROTACs recruit an E3 ubiquitin ligase to a given substrate protein, resulting in its targeted degradation through the endogenous ubiquitin-proteasome system (UPS). PROTAC consists of three chemical elements: a …Read More >

Resource Type: Latest Science Poster
Resource Topic: Biomarkers Cell-based Assays Cells and Protein Science in vivo Pharmacology Lead Optimization Target Identification and Validation Target-Specific Assays Targeted Protein Degradation

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Structure determination: comparison of methods

WuXi AppTec offers comprehensive structural generation solutions for today´s challenging targets. Our experts provide insights and data to support hit finding through to lead optimization.

Resource Type: Brochure Infographic
Resource Topic: Biophysical Assays Cells and Protein Science Hit Finding Hit-to-Lead Lead Optimization Structural Biology Target Identification and Validation

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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

Resource Type: Publication
Resource Topic: Antibodies Biomarkers Cells and Protein Science CRISPR/Cas9 Immunology Oncology Screening Libraries Target Identification and Validation Target-Specific Assays Tumor Models

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