Knowledge Library

Protein Science Platform

Benefiting from 15 years of expertise in protein production, the protein science platform within WuXi Biology has successfully served hundreds of global clients. Our protein science specialists are at the forefront of drug discovery efforts, offering a wide range of services including protein production, isotope labeling, and customized conjugation across all major target classes. We …Read More >

Resource Type: Brochure, Case Study
Resource Topic: Cells and Protein Science

VIEW

EML4-ALK Cell Lines and In Vivo Models

The EML4-ALK fusion gene occurs in approximately 5% of non-small-cell lung cancers (NSCLCs), making this oncogene an important drug target.  The development of ALK tyrosine kinase inhibitors (ALK-TKIs) has been a major advance in treating NSCLC with this fusion gene, but acquired resistance to ALK-TKIs ultimately limits their use.  To support the development of next-generation …Read More >

Resource Type: Latest Science, Presentation
Resource Topic: Cells and Protein Science, Oncology, Tumor Models

VIEW

Parallel Purification of High-Quality Therapeutic Targets

Learn about our semi-automated chromatography platform for parallel purification of high-quality therapeutic targets.  At PEGS Europe 2023, WuXi AppTec scientists described an automated workflow integrated with a serial size exclusion platform, resulting in a complete purification scheme for the rapid purification of high-quality proteins expressed in E. coli, insect cells, and mammalian cells.  This approach …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Cells and Protein Science

VIEW

Jurkat Reporter Cell Lines for Immunotherapy Drug Screening

WuXi AppTec offers Jurkat reporter cell lines for immunotherapy drug screening.  Our platform includes CD8+, TCR knockout and CD16-expressing Jurkat-NFAT-Luc reporter cell lines, and validated assays (using co-cultures of Raji or A375 tumor cells) to evaluate the activity of CARs, TCRs, and bispecific antibodies.  Leverage our portfolio of reporter cell lines to accelerate your research! …Read More >

Resource Type: Latest Science, Presentation
Resource Topic: Cell-based Assays, Cells and Protein Science, Immunology, Oncology

VIEW

PRMT5-WDR77 Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biophysical Assays, Cells and Protein Science, Lead Optimization, Structural Biology

VIEW

PIK3alpha Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biophysical Assays, Cells and Protein Science, Lead Optimization, Structural Biology

VIEW

NLRP3 Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biophysical Assays, Cells and Protein Science, Structural Biology

VIEW

KRAS Services Platform

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biophysical Assays, Cells and Protein Science, Hit-to-Lead, Lead Optimization, Structural Biology

VIEW

KRAS-related Genetically Engineered Cell Lines and In Vivo Models

KRAS mutant proteins that drive cancer development are highly similar in sequence and structure. Direct inhibitors are most likely to bind to the catalytic domain of KRAS. However, recent studies have found that KRAS mutants can also be targeted by heterogeneous sites, to develop covalent inhibitors of KRAS mutants. The discovery of inhibitors that selectively …Read More >

Resource Type: Latest Science, Presentation
Resource Topic: Biochemical Assays, Biophysical Assays, Cell-based Assays, Cells and Protein Science, Hit Finding, Hit-to-Lead, Lead Optimization, Oncology, Small Molecules, Tumor Models

VIEW


Resource Topics
× peptide, amino acid

Contact An Expert Today!