Knowledge Library

OncoWuXi Newsletter December 2022

Resource Type: Latest Science, Newsletter
Resource Topic: Autoimmune and Inflammatory Diseases, Biochemical Assays, Biomarkers, Candidate Selection, Cell-based Assays, DRUG DISCOVERY AND INNOVATION, Hit Finding, Hit-to-Lead, Immunology, Lead Optimization, Oncology, Phenotypic Assays, Rare Diseases, Target Identification and Validation, Tumor Models

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WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >

Resource Type: Brochure
Resource Topic: Antibodies, Biochemical Assays, Biomarkers, Cell-based Assays, Cells and Protein Science, Central Nervous System & Pain, Hit Finding, Hit-to-Lead, in vitro biology, Lead Optimization, Phenotypic Assays, Rare Diseases, Safety and Early Toxicity, Small Molecules, Target Identification and Validation

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OncoWuXi Newsletter November 2022

Resource Type: Newsletter
Resource Topic: Antibodies, Antibody Drug Conjugate, Autoimmune and Inflammatory Diseases, Biomarkers, Cell-based Assays, Cells and Protein Science, Hit-to-Lead, Lead Optimization, Oncology

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How Does It Work? | Aptamers

Nucleic acids have long been regarded as biological compounds for storing and transferring information. However, their functionalities are far more diverse than this – ranging from gene regulation to enzymatic catalysis. One type of unconventional nucleic acid is the aptamer. Aptamers are short, single stranded nucleic acids that fold into highly specific structures. They bind …Read More >

Resource Type: Video
Resource Topic: Biomarkers, Oligonucleotides, Oncology, Target Identification and Validation

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PD-1 Blockade Protein in 4th Generation Armored CAR-T Cells Enhances Cytotoxicity Effect with in vitro Re-challenge System

Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that express a surface receptor to recognize tumor-associated antigens (TAA). CAR-T cell therapy have demonstrated remarkable success with hematological malignancies. However, limited headway has been made towards solid tumor, due to various challenges, including recognition of tumor-specific antigen trafficking and penetration, localization and survival within …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Antibodies, Biomarkers, CAR-T Cell, Cell Therapies, Cell-based Assays, Cells and Protein Science, Oncology, Target Identification and Validation

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Engineered Oncolytic Viruses Expressing Immunomodulatory Genes Enhances In Vitro Anti-Tumor Cellular Immune Responses

While chemo- and radio-therapy are considered the first-line of treatment for most cancers, its serious side effects have led to continuous innovation and discovery of new anti-tumor treatments. Oncolytic viruses (OVs) possess a magnitude of mechanism of action to elicit anti-tumor immune response, including OVs innate cytotoxicity and enhanced anti-tumor immunity by inserting immunomodulatory genes. …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Biomarkers, Cell-based Assays, Immunology, in vitro biology, Oncology, Oncolytic Viruses, Phenotypic Assays, Target Identification and Validation

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Pain Discovery Assays & In Vivo Models

WuXi AppTec offers a comprehensive platform to evaluate lead candidates targeting various types of pain, including inflammatory, neuropathic, and fibromyalgia-like pain and osteoarthritis. Our expertise and experience allow us to offer an extensive portfolio of services supporting drug discovery and development, from target discovery to translational research and clinical biomarker testing and beyond. Full-scale molecular …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays, Biomarkers, Cell-based Assays, Central Nervous System & Pain, in vitro biology, in vivo Pharmacology, Lead Optimization, Target Identification and Validation, Target-Specific Assays

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HIJACKING CELLULAR MECHANISMS TO TREAT COMPLEX DISEASES

Resource Type: White Paper
Resource Topic: Biochemical Assays, Biomarkers, Biophysical Assays, Cell-based Assays, DRUG DISCOVERY AND INNOVATION, in vitro biology, Oligonucleotides, Oncology, Rare Diseases, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation

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RARE DISEASES: OPPORTUNITIES AND CHALLENGES FOR TREATMENTS DELIVERED BY ADENO-ASSOCIATED VIRUSES

Resource Type: White Paper
Resource Topic: Biomarkers, Gene Therapies, in vivo Pharmacology, Rare Diseases, Target Identification and Validation

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Resource Topics
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