Knowledge Library

Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors

Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) have emerged as key regulators of neuronal degeneration and axon growth.  WuXi AppTec scientists recently contributed to a research article in the Journal of Medicinal Chemistry demonstrating the use of ligand- and structure-based drug design approaches to discover an amino-pyrazine chemical series of DLK and …Read More >

Resource Type: Latest Science Publication
Resource Topic: Biochemical Assays Biomarkers Central Nervous System & Pain Discovery Chemistry Lead Optimization Small Molecules

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In Vitro Imaging Services

Offering a comprehensive platform of in vitro imaging-based assays to screen compounds for cancer, inflammation, and autoimmune diseases. Our services include: Imaging assays for cell proliferation and apoptosis Imaging assays for cell cycle analysis Cell-based functional assays, including: Antibody internalization Live-cell immunocytochemistry Cellular movement and morphology monitoring Assays for 3D cell models, including: Spheroid growth …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Biomarkers Cell-based Assays Hit-to-Lead Lead Optimization Oncology Phenotypic Assays Target Identification and Validation

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OncoWuXi Newsletter December 2022

Resource Type: Latest Science Newsletter
Resource Topic: Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Candidate Selection Cell-based Assays CRISPR/Cas9 DRUG DISCOVERY AND INNOVATION Hit Finding Hit-to-Lead Immunology Lead Optimization Oncology Phenotypic Assays Rare Diseases Target Identification and Validation Tumor Models

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WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >

Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Central Nervous System & Pain Hit Finding Hit-to-Lead in vitro biology Lead Optimization Phenotypic Assays Rare Diseases Safety and Early Toxicity Small Molecules Target Identification and Validation

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OncoWuXi Newsletter November 2022

Resource Type: Newsletter
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biomarkers Cell-based Assays Cells and Protein Science Hit-to-Lead Lead Optimization Oncology

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How Does It Work? | Aptamers

Nucleic acids have long been regarded as biological compounds for storing and transferring information. However, their functionalities are far more diverse than this – ranging from gene regulation to enzymatic catalysis. One type of unconventional nucleic acid is the aptamer. Aptamers are short, single stranded nucleic acids that fold into highly specific structures. They bind …Read More >

Resource Type: Video
Resource Topic: Biomarkers Oligonucleotides Oncology Target Identification and Validation

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PD-1 Blockade Protein in 4th Generation Armored CAR-T Cells Enhances Cytotoxicity Effect with in vitro Re-challenge System

Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that express a surface receptor to recognize tumor-associated antigens (TAA). CAR-T cell therapy have demonstrated remarkable success with hematological malignancies. However, limited headway has been made towards solid tumor, due to various challenges, including recognition of tumor-specific antigen trafficking and penetration, localization and survival within …Read More >

Resource Type: Latest Science Poster
Resource Topic: Antibodies Biomarkers CAR-T Cell Cell Therapies Cell-based Assays Cells and Protein Science Oncology Target Identification and Validation

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Engineered Oncolytic Viruses Expressing Immunomodulatory Genes Enhances In Vitro Anti-Tumor Cellular Immune Responses

While chemo- and radio-therapy are considered the first-line of treatment for most cancers, its serious side effects have led to continuous innovation and discovery of new anti-tumor treatments. Oncolytic viruses (OVs) possess a magnitude of mechanism of action to elicit anti-tumor immune response, including OVs innate cytotoxicity and enhanced anti-tumor immunity by inserting immunomodulatory genes. …Read More >

Resource Type: Latest Science Poster
Resource Topic: Biomarkers Cell-based Assays Immunology in vitro biology Oncology Oncolytic Viruses Phenotypic Assays Target Identification and Validation

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Pain Discovery Assays & in vivo Studies

WuXi Discovery Services supports all of your research needs, including target discovery, in vitro and in vivo pharmacology, translational research and clinical biomarker testing, to enable drug discovery for your target compound for pain. Full-scale molecular characterizations from gene/protein expression in vitro functional assays with validation of GPCR, Kinase and ion channel targets Selectivity profiling …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays Biomarkers Cell-based Assays Central Nervous System & Pain in vitro biology in vivo Pharmacology Lead Optimization Target Identification and Validation Target-Specific Assays

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