Systemic sclerosis (also known as scleroderma) is a chronic autoimmune disease that leads to the buildup of scar tissue in various internal organs, as well as the skin. Fibrosis is a key feature of systemic sclerosis, where uncontrolled production of collagen and other extracellular matrix proteins by fibroblasts leads to excess connective tissue accumulation. This …Read More >

Synthetic lethality, where combining two non-lethal mutations results in cell death, is exploited in cancer therapy, with PARP inhibitors like olaparib targeting BRCA-deficient cells by exploiting this interaction.  Werner syndrome helicase (WRN) is a synthetic lethal target in cancers with microsatellite instability due to impaired DNA mismatch repair.  WRN is synthetically lethal with MLH1, a …Read More >

Polycythemia vera (PV) is a chronic myeloproliferative disorder, a type of blood cancer characterized by the overproduction of red blood cells (erythrocytosis) which can lead to thicker blood and an increased risk of blood clot.  Most cases of PV are caused by a point mutation in the JAK2 gene (JAK2-V617F). To support drug discovery teams …Read More >

Epilepsy is a chronic brain disorder characterized by recurring seizures, which are episodes of uncontrolled and abnormal electrical activity in the brain that can cause changes in behavior, sensations, awareness, and movement.  Epilepsy has a wide range of consequences, impacting neurobiology, cognition, and psychosocial well-being. To support drug discovery teams focused on epilepsy research, our …Read More >

Rare neurological diseases are conditions affecting the nervous system that occur infrequently, with examples including Huntington’s disease, Rett syndrome, and Amyotrophic Lateral Sclerosis (ALS). These rare disorders can be classified into various categories based on the affected systems/organs, among which, neuroinflammatory & neuroimmunology-related disorders, movement disorders, and motor neuron disease show higher prevalence. To support …Read More >

Asthma is a chronic, lower airway disease characterized by persistent inflammation and hyperreactivity. Asthma involves a complex immune response, with T-helper 2 (Th2) cells playing a central role, leading to activation of eosinophils and increased levels of IgE antibodies. Clinically, airflow obstruction in asthma often is not fully reversible, and many asthmatic subjects experience an …Read More >

BRCA1 and BRCA2 proteins are key components of the homologous recombination repair pathway for repairing double-stranded DNA breaks.  Mutations in BRCA genes can significantly increase the risk of certain cancers such as breast, ovarian, pancreatic, and prostate cancer. To mimic the effects of BRCA2 deficiency in humans, WuXi Biology has constructed a BRCA2 deficient mouse …Read More >

Cyclin-dependent kinases (CDKs) and their cyclin regulatory subunits form complexes that are essential for driving abnormal growth processes in cancer cells, making these proteins important targets for cancer treatment. To support the discovery of novel CDK inhibitors, the WuXi AppTec Discovery Biology Structural Biology platform provides a wide range of biophysical, X-ray crystallography, and cryo-EM …Read More >

Signal transducer and activator of transcription (STAT) proteins are key mediators of cellular immunity, proliferation, apoptosis, and differentiation. STATs are known to play a key role in the pathogenesis of many different diseases (including cancer) and the development of drugs directly or indirectly targeting STAT signaling is a major focus for researchers. The WuXi AppTec …Read More >