Knowledge Library

Targeted Protein Degradation of Mutant ER-alpha

Estrogen receptor α (ERα) is considered the main driver in more than 70% of all breast cancers, making this transcription factor an important drug target.  Activating point mutations in the ERα gene, especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies, and there is an urgent need to develop new strategies …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oncology Targeted Protein Degradation Tumor Models

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siRNA Efficacy in a Xenograft Tumor Model

Protein kinase N3 (PKN3) is a serine/threonine kinase implicated in tumor progression across multiple cancer types.  PKN3 mRNA is almost undetectable in normal adult tissues but is upregulated in various cancer cells, indicating that siRNA may be a promising approach to inhibit tumor growth by reducing the expression of PKN3.  WuXi AppTec scientists established different siPKN3 molecules and evaluated …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oligonucleotides Oncology Tumor Models

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Paclitaxel-Resistant Tumor Models

Despite the excellent clinical response to paclitaxel therapy, drug resistance inevitably develops in subsequent treatments. The mechanisms for resistance to paclitaxel include drug efflux transporter overexpression, altered apoptotic gene expression, and changes associated with microtubules to reduce the influence of this chemotherapeutic agent. The development of targeted therapies for overcoming paclitaxel resistance represents an unmet medical …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oncology Tumor Models

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NK Cell Humanized Tumor Models

NK cells are effector innate lymphoid cells (ILCs) that do not require antigen-specific priming. NK cells are not only killer cells that help to suppress tumors, but also are involved in the generation and maintenance of adaptive immune responses.  The process of antibody-dependent cell-mediated cytotoxicity (ADCC) makes use of innate immune cells which provide antitumor …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Immunology Oncology Tumor Models

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Orthotopic and Metastasis Tumor Models in Rats

Rat tumor models are a better mimic of human pathology compared to mice. The tumor stroma component of rats is about 1.5 to 2-fold higher relative to mice. Rats are considered an ideal model for preclinical efficacy studies, as they are physiologically, metabolically, and genetically more similar to humans.  To support drug discovery teams, WuXi …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oncology Tumor Models

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T-DXd Resistant Tumor Models with ABCG2

Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads, show great potential as cancer therapies.  However, primary and secondary resistance is frequently observed, and development of next generation ADCs necessitates the establishment of resistant tumor models.  One mechanism of resistance involves efflux of the ADC payload by the transporter …Read More >

Resource Type: Presentation
Resource Topic: Antibody Drug Conjugate Oncology Tumor Models

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EML4-ALK Cell Lines and In Vivo Models

The EML4-ALK fusion gene occurs in approximately 5% of non-small-cell lung cancers (NSCLCs), making this oncogene an important drug target.  The development of ALK tyrosine kinase inhibitors (ALK-TKIs) has been a major advance in treating NSCLC with this fusion gene, but acquired resistance to ALK-TKIs ultimately limits their use.  To support the development of next-generation …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cells and Protein Science Oncology Tumor Models

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High-Dimensional Flow Cytometry Platform

High-dimensional (HD) flow cytometry allows researchers to perform deep phenotyping of immune cells at the single cell level with increased accuracy and sensitivity.  This technology enables complex pathway characterization and data integration for the identification of biomarkers used in immunotherapy.  WuXi AppTec offers a comprehensive panel of HD flow cytometry services, with more than 100 …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases Biomarkers Oncology Phenotypic Assays

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Immune-Avatar Humanized Tumor Models

To support antitumor efficacy testing and address the challenges of clinical translatability, WuXi AppTec offers extensive panels of immune-avatar humanized mouse models. Our platform includes hPBMC, hHSC, and hNK humanized models with enabling studies from our platform of over 1,700 CDX and PDX models. These well-established models cover multiple cancer types, including breast, lung, liver, …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oncology Tumor Models

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