BRCA2 Deficient DLD-1 Model

BRCA1 and BRCA2 proteins are key components of the homologous recombination repair pathway for repairing double-stranded DNA breaks.  Mutations in BRCA genes can significantly increase the risk of certain cancers such as breast, ovarian, pancreatic, and prostate cancer.

To mimic the effects of BRCA2 deficiency in humans, WuXi Biology has constructed a BRCA2 deficient mouse model based on the colorectal cancer cell line DLD-1.  This model can be valuable for evaluating the efficacy of targeted therapies, like PARP inhibitors, which are particularly effective against cancers with BRCA mutations due to their reliance on error-prone DNA repair mechanisms that arise in the absence of BRCA function.

BRCA2-Deficient DLD-1 Cell Line and In Vivo Model

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