Sclerosis and Fibrosis Disease Models

Systemic sclerosis (also known as scleroderma) is a chronic autoimmune disease that leads to the buildup of scar tissue in various internal organs, as well as the skin. Fibrosis is a key feature of systemic sclerosis, where uncontrolled production of collagen and other extracellular matrix proteins by fibroblasts leads to excess connective tissue accumulation. This excessive fibrosis disrupts the normal tissue architecture of affected organs, causing dysfunction and potentially leading to organ failure.

Selecting preclinical in vivo models that are reflective of clinical outcome is a key challenge in the development of new therapies to treat fibrotic diseases. Our fibrosis model platform offers insight into the pathogenesis of tissue and organ fibrosis, to support the discovery of effective therapies for treating fibrosis and sclerosis.

Systemic Sclerosis and Fibrosis Models

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