One Stop Target-to-Hit Platform: Werner Syndrome Helicase (WRN)
Werner syndrome helicase (WRN) is a key drug target for cancers with microsatellite instability. To support the discovery of potent...
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Emerging Modalities in Drug Discovery
In this webinar, we present the latest advances and challenges facing researchers focused on new and emerging modalities in drug...
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Oligonucleotide Therapeutics: Drug Discovery Through Tightly Coupled Chemistry and Biology
Designing effective oligonucleotide therapeutics for clinical applications involves understanding both the chemistry and biology of nucleic acids. In this white...
Continue Reading DELvision: Improving Data-Driven Drug Discovery
DELvision is a powerful DNA encoded library (DEL)-based toolset for AIphaFold-assisted drug discovery and target sciences. In contrast to conventional...
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Alopecia Mouse Models
Our in vivo alopecia platform is comprised of both non-cicatricial and cicatricial alopecia models, including skin graft-induced alopecia areata (AA)...
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New study by Promega and WuXi AppTec demonstrates novel chemical probes from DELs
As reported in Business Wire: DNA-Encoded Libraries (DELs) and NanoBRET Target Engagement Assays Accelerate Drug Discovery: “The authors demonstrate that...
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Oncolytic Virus Platform
Oncolytic viruses (OVs) are emerging as a promising therapeutic approach for treating cancer. OVs are capable of both tumor-specific cell...
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Case Study: Clinically Relevant NASH Animal Model
In this case study, we demonstrate clinical relevance of the HFD+CCL4 (high-fat diet and carbon tetrachloride) NASH animal model. Improvement...
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Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)
WuXi AppTec scientists contributed to a study which identified a novel, indole-based, selective estrogen receptor degrader (SERD), designated LX-039. The authors...
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