Obesity is a significant risk factor for developing conditions like type 2 diabetes, heart disease, stroke, and several types of cancer.  The cannabinoid-1 (CB1) receptor plays a significant role in regulating energy homeostasis, including appetite, food intake, and metabolism, and this receptor is emerging as a promising target for the treatment of obesity.  Although rimonabant, …Read More >

Hit validation is a crucial step in drug discovery based on DNA-encoded libraries (DEL). Rapid and accurate resynthesis of compounds, along with subsequent validation, can significantly accelerate the drug discovery process. The groups of Professors Jörg Scheuermann and Renato Zenobi from ETH Zurich developed a new method for validating on-DNA compounds with the support of …Read More >

The ATP-adenosine pathway plays a crucial role in regulating immune responses, including those involved in combating tumors. CD39 is an enzyme that breaks down ATP into adenosine. Adenosine, in turn, can suppress the immune system, potentially hindering the body’s ability to fight cancer. By inhibiting CD39, researchers aim to increase ATP levels in the tumor …Read More >

Choose excellence, choose WuXi Biology – your reliable partner in Targeted Protein Degradation (TPD) drug discovery. Since 2016, we have developed comprehensive discovery platforms capable of investigating the complete TPD functional cycle, from binary and ternary complex formation to protein ubiquitination and degradation. Our broad and deep expertise spans diverse TPD modalities, including PROTACs®, molecular …Read More >

Introduction： OncoWuXi Express will continue to keep you informed about updates to our online pharmacology model database (OncoWuXi Database), as well as our recent progress in preclinical research. In this issue, we showcase animal models related to Parkinson’s disease. https://onco.wuxiapptec.com Introduction Pathogenesis of Parkinson’s Disease Parkinson’s Disease (PD) is a widely prevalent neurodegenerative disorder globally. …Read More >

Antibody-drug conjugates (ADCs) are increasingly demonstrating their value in cancer treatment, especially in combination therapies and for targeting resistant cancer cell populations.  The ability of ADCs to deliver highly potent cytotoxic payloads directly to cancer cells that express a target antigen makes them a promising approach for targeted therapy.  However, the complex structure and mechanism …Read More >

Since 2016, WuXi AppTec has built a comprehensive discovery platform focused on Targeted Protein Degraders (TPDs).  Our platform enables research teams to investigate the complete TPD functional cycle, from binary and ternary complex formation to protein ubiquitination and degradation.  Our end-to-end services encompass over 20 assay technologies, 10+ types of TPD molecules, and one-stop screening …Read More >

Introduction: Obesity has emerged as a pressing global public health issue, with its prevalence escalating at an unprecedented rate across the world. Body Mass Index (BMI) is a commonly used indicator to assess the degree of obesity. According to the World Obesity Atlas 2025, by 2030, over 2.9 billion adults globally will have a high …Read More >

Systemic lupus erythematosus (SLE) is a serious, chronic autoimmune disorder characterized by a heterogeneous clinical presentation, in which various organs and systems are affected in different ways and with varying degrees of severity.  SLE is characterized by an autoimmune reaction involving the innate and adaptive immune systems, including dendritic cells, T cells, and B cells. …Read More >