Resources Archive - Page 24 of 47

GPCR-Membrane Protein Platform

WuXi AppTec provides a comprehensive platform of advanced biophysical assays and structural biology services to accelerate lead optimization efforts focused...

Advances and Biological Evaluation of Oligonucleotide Drugs

Introduction: As a therapeutic modality, oligonucleotides have a target abundance, persistent efficacy, high specificity, greater success rate and shorter R/D...

Biophysical and Structural Biology Methods Enable Fragment-Based Ligand Discovery

Powerful biophysical and structural biology tools enable the study of large numbers of fragments and are opening new possibilities in...

AAV Gene Therapy: Discovery and Optimization

Viral vectors, such as AAV, have emerged as one of the most commonly used gene delivery vehicles. In this webinar,...

Parallel Purification of High-Quality Therapeutic Targets

Learn about our semi-automated chromatography platform for parallel purification of high-quality therapeutic targets. At PEGS Europe 2023, WuXi AppTec scientists...

Combined Inhibition of KRAS G12C and PD1 Boosts Therapeutic Efficacy via Conditioning of Tumor Microenvironment

SITC Poster #466: Mutant KRAS is linked to PD-L1 expression, and oncogenic RAS signaling promotes an immunosuppressive tumor microenvironment by...

Progress and Challenges in Tumor Vaccine Development

Introduction: Cancer is a major public health concern, and this disease is a leading cause of death worldwide. There are...

Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

DNA-dependent protein kinase (DNA-PK) plays an important role in the overall survival and proliferation of cells, making this enzyme an...

Osimertinib-Resistant Cell Lines and Models

Despite the robust clinical activity exerted by osimertinib, a majority of patients eventually exhibit disease progression while receiving this drug. ...

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