One Stop Target-to-Hit Platform: Protein arginine methyltransferase 5 (PRMT5)
Protein arginine methyltransferase 5 (PRMT5) is an enzyme which plays an essential role in a wide range of cellular processes. ...
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One Stop Target-to-Hit Platform: Cyclin-dependent kinase 2 (CDK2)
Cyclin-dependent kinase 2 (CDK2) and its respective cyclin E1 and cyclin A2 complexes are essential to driving abnormal growth processes...
Continue Reading One Stop Target-to-Hit Platform: Werner Syndrome Helicase (WRN)
Werner syndrome helicase (WRN) is a key drug target for cancers with microsatellite instability. To support the discovery of potent...
Continue Reading DELvision: Improving Data-Driven Drug Discovery
DELvision is a powerful DNA encoded library (DEL)-based toolset for AIphaFold-assisted drug discovery and target sciences. In contrast to conventional...
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New study by Promega and WuXi AppTec demonstrates novel chemical probes from DELs
As reported in Business Wire: DNA-Encoded Libraries (DELs) and NanoBRET Target Engagement Assays Accelerate Drug Discovery: “The authors demonstrate that...
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Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)
WuXi AppTec scientists contributed to a study which identified a novel, indole-based, selective estrogen receptor degrader (SERD), designated LX-039. The authors...
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DELs enable the development of BRET probes for target engagement studies in cells
WuXi AppTec scientists recently contributed to a research article in Cell Chemical Biology demonstrating the successful conversion of ligands identified...
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In Vitro Immunology Assay Platform
Leverage our panel of in vitro immunology assays to accelerate your lead optimization efforts. WuXi AppTec offers a comprehensive platform of...
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CD34+ Hematopoietic Stem Cell Differentiation Platform
To accelerate screening and lead optimization efforts involving immune cell differentiation, WuXi AppTec offers a comprehensive CD34+ hematopoietic stem cell...
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