Stages Archives - Page 7 of 19

Inhibition of the hERG potassium ion channel by non-nucleoside CMV polymerase antiviral inhibitors

WuXi AppTec scientists collaborated on a study to characterize a series of pyrroloquinoline derivatives that were designed and synthesized to...

AACR 2023: Comparison of two DTH models for T cell-mediated immunity

To characterize the immunity profile of the most widely used delayed-type hypersensitivity (DTH) models, WuXi AppTec scientists built 2,4-dinitrofluorobenzene (DNFB)...

Recent Advances in Library Synthesis to Accelerate Medicinal Chemistry Research

Learn how parallel medicinal chemistry (PMC) and high-throughput experimentation (HTE) can provide a more focused approach to target molecules, resulting...

Immune Profiling Platform

We offer an extensive panel of cutting-edge immune profiling and biomarker discovery services to support: Target discovery and validation Drug...

Inflammatory Bowel Disease Models

We offer an extensive panel of inflammatory bowel disease models in mice and rats, including genetically modified, chemically induced, and...

DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor

Macrocyclic peptides are an emerging molecular class for targeting intracellular protein–protein interactions (PPIs) and for providing an oral modality for...

Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery

Drug Discovery Chemistry Conference 2023 WuXi AppTec has developed technologies to facilitate RNA small molecule screening, an exciting frontier in...

Biophysical and Structural Biology Methods Enable Fragment-based Covalent Ligand Discovery of Human BTK

Drug Discovery Chemistry Conference 2023 Powerful biophysical and structural biology tools enable the study of large numbers of covalent fragments...

DNA-Encoded Libraries for the Discovery of Small-Molecule Hits

Drug Discovery Chemistry Conference 2023 DNA-Encoded library (DEL) screening is now commonly used in the pharmaceutical industry to find novel...

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