Knowledge Library

DNA-encoded libraries for academic – DELopen Handbook

DNA-encoded libraries for academic | Open Access to DEL Self-service platform for academia to utilize the full potential of DEL technology DELopen provides free access to DNA-encoded libraries (DEL) for academic users and encourages an open, community-based approach to data sharing.
Resource Type: Brochure
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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DEL Screening – DELight Handbook

DEL Screening | WuXi AppTec DELight Kit  Faster and Lighter Drug Discovery DELight kit containing 58 libraries and 10.8 billion compounds, buffers and a step-by-step online experimental manual. Drug developers perform affinity selection according to the manual and return the sample to WuXi AppTec upon completion.
Resource Type: Brochure
Resource Topic: Chemical Biology and Proteomics DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation Targeted Protein Degradation

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Discovery Chemistry Outsourcing Services

Global Leader in Discovery Chemistry Outsourcing Services Based on FTE (Full Time Equivalent) Model | Customization to Client’s Synthetic Chemistry with high productivity, quality, speed, and reliability Project Management:  we manage project timelines and compound flow Medicinal Chemistry: we provide compound design and project management Integrated Projects from targets to hits to leads to preclinical …Read More >
Resource Type: Brochure
Resource Topic: Candidate Selection Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead Lead Optimization Mass Spectrometry-based Assays Quantum Mechanics Small Molecules

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Cell Line-Derived Xenograft (CDX) Tumor Models

A large collection of cell line-derived xenograft (CDX) tumor models 215 validated models, SOC data available World leading imaging based orthotopic/metastatic CDX platform 28 models covering 16 tumor types
Resource Type: Brochure
Resource Topic: in vivo Pharmacology Lead Optimization Oncology Oncolytic Viruses Small Molecules Target Identification and Validation Tumor Models

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WuXi Oncology and Immuno-Oncology Services

Integrated Oncology and Immuno-oncology Platform to Enable Translational Science from Drug Discovery to Clinical Biomarker CRISPR/Cas9 Gene Editing In Vitro Assay and HTS Tumor models Tumor Cell Panel and Screening Immunology and Immuno-oncology Platform Clinical Biomarker
Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Chemical Biology and Proteomics Clinical Bioanalysis CRISPR/Cas9 Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit-to-Lead Immunology in vitro biology in vivo Pharmacology Lead Optimization Oncology Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays Targeted Protein Degradation Tumor Models

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Cancer Cell Panel

The Biology Unit offers a diverse in vitro screening panel of over 378 authenticated, well-validated human cancer cell lines across 21 organs/tissues. The cancer cell panel provides powerful tools for cancer research and drug discovery. Key features of WuXi cancer cell panel include: High quality cell banking system: mycoplasma-proof and STR verified 353 validated and …Read More >
Resource Type: Brochure
Resource Topic: Cell-based Assays Cells and Protein Science Hit-to-Lead Lead Optimization Oncology Phenotypic Assays Small Molecules Target Identification and Validation

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Identification of Tofacitinib, Filgotinib and Ruxolitinib on experimental Sjögren’s syndrome model in mice

Sjögren’s syndrome, which affects hundreds of millions of people worldwide, is a chronic autoimmune disorder characterized by leukocytic infiltration into the exocrine glands, such as the salivary and lacrimal glands. However, the pathological mechanism remains to be elucidated, and novel treatments are urgently needed. Over the past decade, extensive progress has been made in the …Read More >
Resource Type: Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology Lead Optimization Rare Diseases Small Molecules Structural Biology

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