Knowledge Library

WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >
Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Central Nervous System & Pain Hit Finding Hit-to-Lead in vitro biology Lead Optimization Phenotypic Assays Rare Diseases Safety and Early Toxicity Small Molecules Target Identification and Validation

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Engineered Oncolytic Viruses Expressing Immunomodulatory Genes Enhances In Vitro Anti-Tumor Cellular Immune Responses

While chemo- and radio-therapy are considered the first-line of treatment for most cancers, its serious side effects have led to continuous innovation and discovery of new anti-tumor treatments. Oncolytic viruses (OVs) possess a magnitude of mechanism of action to elicit anti-tumor immune response, including OVs innate cytotoxicity and enhanced anti-tumor immunity by inserting immunomodulatory genes. …Read More >
Resource Type: Latest Science Poster
Resource Topic: Biomarkers Cell-based Assays Immunology in vitro biology Oncology Oncolytic Viruses Phenotypic Assays Target Identification and Validation

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond
Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Quality Control for DNA-Encoded One-Bead-One-Compound (OBOC) Libraries
Resource Type: Presentation Video
Resource Topic: Biochemical Assays Biophysical Assays Chemical Biology and Proteomics DNA-Encoded Library (DEL) Hit Finding in vitro biology Phenotypic Assays Screening Libraries Small Molecules Target Identification and Validation

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Cancer Immunotherapy and the Application of In Vitro Immunoassays in Drug Development
Resource Type: Webinar
Resource Topic: Antibodies Autoimmune and Inflammatory Diseases Biochemical Assays Cell-based Assays Hit-to-Lead Immunology Lead Optimization Oncology Phenotypic Assays Small Molecules Target Identification and Validation Target-Specific Assays

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Optimizing Drug Discovery Pipelines with Biophysical Methods
Resource Type: Webinar
Resource Topic: Antibodies Biochemical Assays Biomarkers Biophysical Assays Cell-based Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Oncology Phenotypic Assays Screening Libraries Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation

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CRISPR library screens identify frequent cancer mutations regulating PD-1 blockade response

AACR Annual meeting 2021 Wenrong Zhou1,* , Min Long2,3* , Tianyu Song3,* , Qiangqiang Fan1 , Zhengang Peng1 , Yong Cang3 , Qunsheng Ji1  1 Oncology and Immunology Unit, Research Service Division, WuXi AppTec (Shanghai) Co., Ltd., China; 2 Life Sciences Institute, Zhejiang University, Hangzhou, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, …Read More >
Resource Type: Poster
Resource Topic: CRISPR/Cas9 Gene Manipulation Gene Therapies Oncology Phenotypic Assays Screening Libraries Target Identification and Validation

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Engineered cell line panel complemented with in vivo models to enable next-generation target therapy discovery in cancer

 AACR Annual meeting 2021   Authors: Zhixiang Zhang1, Feifei Fan2, Xiaohe Shi2, Xiangyang Zuo2, Qingyang Gu2, Qunsheng Ji1. 1 WuXi AppTec, Shanghai, China; 2 WuXi AppTec, Jiangsu, China Corresponding Author: Qunsheng Ji. Email: ji_qunsheng@wuxiapptec.com   Background  Many cancer types are driven by specific gene aberrances, like gene fusions, mutations and copy number changes. It has led to …Read More >
Resource Type: Poster
Resource Topic: Biomarkers Cell-based Assays Oncology Phenotypic Assays Target Identification and Validation Tumor Models

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Drug Hunter: Discovering New Frontiers in Cancer Treatments & Beyond

INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) As a self-proclaimed drug hunter, Phil Jones is on a mission to identify the next generation of cancer medicines that improve the lives of patients with cancer. He leads a multi-disciplinary team of scientists at The University of Texas MD Anderson Cancer Center’s Institute …Read More >
Resource Type: Article
Resource Topic: Biomarkers CAR-T Cell Cells and Protein Science Chemical Biology and Proteomics DRUG DISCOVERY AND INNOVATION Hit Finding in vitro biology in vivo Pharmacology Oncology Phenotypic Assays Small Molecules Target Identification and Validation

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