Integrated Screening in Hit Identification

Despite the availability of modern screening technologies, identification and optimization of hits against poorly druggable targets remains a significant challenge for drug discovery teams.  Generating hit matter and reference compounds with one screening technology and then screening with a second technology has the potential to be a powerful tool for researchers.

At this year’s Oxford Global Discovery Europe Conference, WuXi AppTec presented a poster highlighting a case study which employed a combination of different screening technologies, structural biology methods, and computational approaches to identify and advance hits with nanomolar potency against p38α.

Discovery Europe _Poster_Integrated Screening_final

Download