Knowledge Library

Cyclin Dependent Kinases: Structural Biology Services

Cyclin-dependent kinases (CDKs) and their cyclin regulatory subunits form complexes that are essential for driving abnormal growth processes in cancer cells, making these proteins important targets for cancer treatment. To support the discovery of novel CDK inhibitors, the WuXi AppTec Discovery Biology Structural Biology platform provides a wide range of biophysical, X-ray crystallography, and cryo-EM …Read More >

Resource Type: Presentation
Resource Topic: Cryo-EM, Structural Biology, X-ray Crystallography

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STAT Family: Structural Biology Services

Signal transducer and activator of transcription (STAT) proteins are key mediators of cellular immunity, proliferation, apoptosis, and differentiation. STATs are known to play a key role in the pathogenesis of many different diseases (including cancer) and the development of drugs directly or indirectly targeting STAT signaling is a major focus for researchers. The WuXi AppTec …Read More >

Resource Type: Presentation
Resource Topic: Cryo-EM, Structural Biology, X-ray Crystallography

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Production and Characterization of Protein Biologics

At the 2024 Protein & Antibody Engineering Summit (PEGS) Europe, Crelux presented a poster highlighting its drug discovery platform for the production and characterization of protein biologics and their antigens. This platform combines construct and expression scouting, customizable high-throughput protein purification, and affinity/kinetics determination using various biophysical techniques, as well as paratope and epitope mapping …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Biophysical Assays, Cells and Protein Science, Cryo-EM, Structural Biology, X-ray Crystallography

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Fibroblast Growth Factor Receptors

Fibroblast growth factor receptor (FGFR) signaling pathways represent promising targets for therapeutics owing to their role in development, tissue, and whole-body homeostasis, as well as in many cancers. To support drug discovery programs, we have established off-the-shelf crystallization systems to enable the determination of high-resolution X-ray crystal structures with a short turnaround time. Together with …Read More >

Resource Type: Presentation
Resource Topic: Cryo-EM, Structural Biology, X-ray Crystallography

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CRBN Structural Biology Services

Targeted protein degradation of disease-causing proteins by the E3 ligase cereblon (CRBN) represents a new therapeutic strategy for addressing challenging-to-treat diseases. To support drug discovery programs, we have established off-the-shelf crystallization and cryo-EM systems to enable the determination of high-resolution X-ray crystal structures with a short turnaround time. Together with our protein production service and …Read More >

Resource Type: Presentation
Resource Topic: Biophysical Assays, Cryo-EM, Structural Biology, Targeted Protein Degradation, X-ray Crystallography

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WRN Helicase: Structural Biology Services

Inhibition of the Werner syndrome RecQ helicase (WRN) is a promising approach for the treatment of cancers commonly associated with microsatellite instability. To support drug discovery programs, we have established off-the-shelf crystallization systems to enable the determination of high-resolution X-ray crystal structures with a short turnaround time. Together with our protein production service and off-the-shelf …Read More >

Resource Type: Presentation
Resource Topic: Biophysical Assays, Cryo-EM, Structural Biology, X-ray Crystallography

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Cryo-EM

We offer established protocols for cryo-EM structure determination, with extensive experience in epitope mapping, formulation characterization, and structure-based drug discovery (SBDD). Our integrated services platform also includes: Biophysical and biochemical screening assays Crystal-grade protein production High-resolution X-ray crystallography

Resource Type: Brochure
Resource Topic: Cryo-EM, Structural Biology

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Resource Topics
× peptide, amino acid

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