Autoimmune and Inflammatory Diseases Archives

Short-Term Mouse Model to Accelerate SLE Drug Discovery

Accelerating SLE Drug Discovery: A Short-Term BM12-Induced Mouse Model for Efficient Drug Screening Systemic lupus erythematosus (SLE) is a chronic...

Efficacy of Biologics in Humanized Mouse Models for IBD

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease, is a chronic, immune-mediated disorder characterized by persistent inflammation...

Psoriasis: Pathogenesis, Treatment, and Evolving Disease Models

Introduction: Autoimmune skin diseases (AISDs) are a group of chronic inflammatory disorders characterized by the immune system mistakenly recognizing self-antigens...

Efficacy of a TL1A Antibody in an Acute Colitis Mouse Model

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease, is a chronic, immune-mediated disorder characterized by persistent inflammation...

Induced Pruritus Model in NHP

The “itch-scratch cycle” is a central pathogenic driver in many pruritic (itch-related) inflammatory skin diseases, such as atopic dermatitis (AD),...

Endometriosis: Animal Models as Tools to Accelerate New Therapeutics

Introduction Endometriosis is a common gynecological condition that significantly impacts the health of women of reproductive age worldwide. Approximately 10%...

Precision-Cut Tissue Slices to Advance Drug Discovery

Precision-cut tissue slices (PCTS) are an effective ex vivo model for studying human diseases, including those involving the tissue microenvironment....

Advancements in Membranous Nephropathy

From Pathogenesis to Therapeutic Innovations Introduction: Membranous nephropathy (MN) has received particular attention among autoimmune kidney disease due to its...

Sclerosis and Fibrosis Disease Models

Systemic sclerosis (also known as scleroderma) is a chronic autoimmune disease that leads to the buildup of scar tissue in...

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