Knowledge Library

Colitis-Associated Cancer Mouse Model

The cumulative impact of chronic inflammation in patients with inflammatory bowel disease (IBD) predisposes them to the development of IBD-associated colorectal cancer. To support drug discovery research in this area, WuXi AppTec has developed a colitis-associated cancer mouse model to reflect the human colon’s carcinogenesis pattern derived from inflammation. Key features of this model include …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases Tumor Models

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Fibrosis Models in Mice and Rats

Selecting preclinical in vivo models that are reflective of clinical outcome is a key challenge in the development of new therapies to treat fibrotic diseases.  To accelerate research focused on pulmonary, renal, and liver fibrosis, WuXi AppTec has established a series of in vivo models supported with anti-fibrotic efficacy data.  Our platform also includes a …Read More >

Resource Type: Presentation
Resource Topic: Autoimmune and Inflammatory Diseases Liver Diseases NASH Respiratory Diseases

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Dianthus Platform: Screening for Modulators of SIK3

Salt-inducible kinases (SIKs) have recently emerged as key regulators of oncogenesis, inflammation, and immune responses, making these enzymes an important drug target. The isoform SIK3 is a novel regulator of tumor-intrinsic resistance to cytotoxic T cell attack. To support the discovery of novel SIK3 modulators, WuXi AppTec offers an integrated platform of ready-to-go biophysical assays …Read More >

Resource Type: Brochure
Resource Topic: Autoimmune and Inflammatory Diseases Biophysical Assays Hit Finding Hit-to-Lead Immunology Metabolic Diseases Oncology

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Atopic Dermatitis Models

Atopic dermatitis (AD) is the most common, chronic inflammatory skin disease.  To support drug discovery research in this area, WuXi AppTec offers a broad platform of validated, in vivo AD models.  Our panel includes DNCB, DNFB, and MC903-induced AD models.  Study readouts include histopathology scoring and measurements of serum IgE levels, transepidermal water loss, and …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

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Alopecia Mouse Models

Our in vivo alopecia platform is comprised of both non-cicatricial and cicatricial alopecia models, including skin graft-induced alopecia areata (AA) in C3H/HeJ mice, cyclophosphamide-induced alopecia in C57BL/6 mice, and androgenetic alopecia (AGA) in C57BL/6 mice. Discover our comprehensive panel of in vivo pharmacology models by clicking here

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

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AACR 2023: Comparison of two DTH models for T cell-mediated immunity

To characterize the immunity profile of the most widely used delayed-type hypersensitivity (DTH) models, WuXi AppTec scientists built 2,4-dinitrofluorobenzene (DNFB) and oxazolone-induced DTH models in both BALB/c and C57BL/6 mice with robust ear thickness as the readout. Check out our comprehensive panel of services related to autoimmune and inflammatory diseases

Resource Type: Latest Science Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology Lead Optimization Respiratory Diseases

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Gout Models

As part of our autoimmune and inflammatory disease platform, we provide an extensive panel of monosodium urate (MSU) induced gout models, including: Air pouch gout models in mice and rats Articular injection induced gout models in mice, rats and rabbits View our wide range of in vitro assays and in vivo animal models related to inflammation …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

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Large Animal Disease Models

Providing a comprehensive panel of large animal disease models across multiple species, including NHP, mini-pig, dog, and rabbit. Models for a wide range of indications, including autoimmune and inflammatory diseases Covering healthy animals, disease models, and animal biobank Multi-disciplinary read-outs (including clinical and pathology scoring, and medical imaging via MRI, X-ray, and endoscopy) Druggability assessment …Read More >

Resource Type: Brochure
Resource Topic: Autoimmune and Inflammatory Diseases Immunology in vivo Pharmacology

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Inflammatory Bowel Disease Models

We offer an extensive panel of inflammatory bowel disease models in mice and rats, including genetically modified, chemically induced, and adoptive transfer-related IBD models. Let our experts help you choose the best IBD animal models to advance your research programs. Learn more about our platform of inflammation models  

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases Hit-to-Lead in vivo Pharmacology Lead Optimization

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