Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we present an evaluation of the efficacy of different JAK subtype inhibitors in a Type II collagen-induced arthritis model, along with corresponding …Read More >

RNA interference using small interfering RNA (siRNA) molecules has emerged as a promising therapeutic modality.  To accelerate the discovery of novel siRNAs, WuXi AppTec has established an integrated platform encompassing siRNA sequence design, chemical synthesis/modification, delivery ligand exploration, and activity/off-target assessment. At the TIDES USA 2024 Conference, our scientists presented a poster showcasing the effectiveness …Read More >

Gout is a common type of inflammatory arthritis linked to abnormal uric acid metabolism, resulting in the accumulation of urate crystal deposits in joints. To support the development of effective gout therapies, precise animal models are needed to properly evaluate drug candidates. At IMMUNOLOGY2024, WuXi AppTec presented a poster highlighting the development of multiple preclinical …Read More >

Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin condition that is characterized by recurrent eczematous lesions. Janus kinase (JAK) inhibitors have been found to be efficacious in treating AD, although their mechanism of action in AD is not fully understood. To support preclinical research in this area, WuXi AppTec presented a poster at IMMUNOLOGY2024 …Read More >

High-dimensional (HD) flow cytometry allows researchers to perform deep phenotyping of immune cells at the single cell level with increased accuracy and sensitivity.  This technology enables complex pathway characterization and data integration for the identification of biomarkers used in immunotherapy.  WuXi AppTec offers a comprehensive panel of HD flow cytometry services, with more than 100 …Read More >

Review of SITC 2023 Annual Meeting The 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) was held this year in San Diego, CA, USA. As one of the most influential international conferences dedicated to cancer immunotherapy, SITC provides attendees with a cross-disciplinary educational and interactive platform. This meeting focuses on discussing and …Read More >

SITC Poster #452: Alopecia areata (AA) is an autoimmune disease characterized by patchy and sudden hair loss without scarring, resulting in a heavy psychological burden on patients. To better understand the pathogenesis and treatment of alopecia areata, we developed a skin grafts-induced alopecia areata model to provide a reproducible, reliable animal model for AA research. …Read More >

SITC Poster #446: Inflammatory bowel disease (IBD) is recognized as an autoimmune disorder characterized by chronic inflammation of the digestive tract. The pathogenesis of IBD is not fully understood and can repeatedly relapse despite clinical therapy. The T cell transfer-induced colitis model enables the study of early inflammation and immunological responses in the colon, such …Read More >

The cumulative impact of chronic inflammation in patients with inflammatory bowel disease (IBD) predisposes them to the development of IBD-associated colorectal cancer. To support drug discovery research in this area, WuXi AppTec has developed a colitis-associated cancer mouse model to reflect the human colon’s carcinogenesis pattern derived from inflammation. Key features of this model include …Read More >