Autoimmune and Inflammatory Diseases Archives

Efficacy of a TL1A Antibody in an Acute Colitis Mouse Model

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease, is a chronic, immune-mediated disorder characterized by persistent inflammation...

MSU-Induced Acute Gouty Arthritis Mouse Model

Gouty arthritis is a common, painful inflammatory condition characterized by the deposition of monosodium urate (MSU) crystals in joints. This...

Induced Pruritus Model in NHP

The “itch-scratch cycle” is a central pathogenic driver in many pruritic (itch-related) inflammatory skin diseases, such as atopic dermatitis (AD),...

Endometriosis: Animal Models as Tools to Accelerate New Therapeutics

Introduction Endometriosis is a common gynecological condition that significantly impacts the health of women of reproductive age worldwide. Approximately 10%...

Precision-Cut Tissue Slices to Advance Drug Discovery

Precision-cut tissue slices (PCTS) are an effective ex vivo model for studying human diseases, including those involving the tissue microenvironment....

Developing Animal Gout Models

Gout is a common type of inflammatory arthritis caused by elevated uric acid levels in the blood. When uric acid...

Advancements in Membranous Nephropathy

From Pathogenesis to Therapeutic Innovations Introduction: Membranous nephropathy (MN) has received particular attention among autoimmune kidney disease due to its...

Sclerosis and Fibrosis Disease Models

Systemic sclerosis (also known as scleroderma) is a chronic autoimmune disease that leads to the buildup of scar tissue in...

International Women’s Day: Safeguarding Women’s Health Across the Lifespan with the Power of Science

Introduction In recognition of International Women’s Day, we spotlight women’s health—a continuously evolving global healthcare issue. The year 2025 marks...

Knowledge Library