Systemic sclerosis (also known as scleroderma) is a chronic autoimmune disease that leads to the buildup of scar tissue in various internal organs, as well as the skin. Fibrosis is a key feature of systemic sclerosis, where uncontrolled production of collagen and other extracellular matrix proteins by fibroblasts leads to excess connective tissue accumulation. This …Read More >

Introduction In recognition of International Women’s Day, we spotlight women’s health—a continuously evolving global healthcare issue. The year 2025 marks the 30th anniversary of the United Nations Fourth World Conference on Women, where the landmark Beijing Declaration was adopted. This pivotal document systematically outlined an action framework for advocating women’s rights, with a particular emphasis …Read More >

Introduction: Women spend about one-third of their lives in menopause or post-menopause, a period that marks the gradual decline of their reproductive capabilities [1, 2]. Menopause typically begins between the ages of 45 and 55 and is marked by 12 consecutive months without menstruation. Menopausal syndrome refers to a series of physiological and psychological symptoms …Read More >

Kidney diseases are complex conditions caused by a variety of factors, including autoimmune diseases, metabolic disorders, infections, drug side effects, and genetics. Kidney diseases can lead to a range of complications, including kidney failure, anemia, electrolyte imbalances, and nerve damage, thereby affecting the quality of life. To drive breakthroughs in this critical field, WuXi AppTec …Read More >

Introduction: Fibrosis is a pathological process characterized by the excessive deposition of extracellular matrix (ECM) within an organ, leading to significant damage to its structure and function, which can potentially impact multiple organs such as the lungs, liver, heart, kidneys, and skin (Fig.1). Notable examples of fibrotic diseases include idiopathic pulmonary fibrosis (IPF), liver cirrhosis, …Read More >

Psoriasis is a chronic autoimmune skin disease characterized by abnormal keratinocyte proliferation and infiltration of inflammatory cells.  The absence of a suitable animal model that accurately mimics the complex phenotype of psoriasis in humans has hindered the development of promising therapeutics to treat this condition. At SITC 2024, WuXi AppTec presented a poster showcasing the …Read More >

Vitiligo is an autoimmune disorder characterized by the progressive destruction of melanocytes in the skin. This condition is driven by the infiltration of endogenous autoreactive CD8+ T cells, which target and destroy melanocytes, resulting in the clinical manifestation of skin depigmentation. As a common acquired skin disease with no highly effective treatments, there is an …Read More >

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that is mediated by genetic, immune, and environmental factors. Due to its long-term, relapsing course, IBD can result in repeated cycles of mucosal damage and repair, potentially increasing the risk of colorectal cancer over time. While current treatments focus on reducing inflammation, they are less …Read More >

OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we showcase various induced acute and chronic pancreatitis models and the evaluation of anti-pancreatic drug efficacy. https://onco.wuxiapptec.com Introduction: Pancreatitis is one of the …Read More >