To characterize the immunity profile of the most widely used delayed-type hypersensitivity (DTH) models, WuXi AppTec scientists built 2,4-dinitrofluorobenzene (DNFB) and oxazolone-induced DTH models in both BALB/c and C57BL/6 mice with robust ear thickness as the readout. Check out our comprehensive panel of services related to autoimmune and inflammatory diseases

As part of our autoimmune and inflammatory disease platform, we provide an extensive panel of monosodium urate (MSU) induced gout models, including: Air pouch gout models in mice and rats Articular injection induced gout models in mice, rats and rabbits View our wide range of in vitro assays and in vivo animal models related to inflammation …Read More >

Providing a comprehensive panel of large animal disease models across multiple species, including NHP, mini-pig, dog, and rabbit. Models for a wide range of indications, including autoimmune and inflammatory diseases Covering healthy animals, disease models, and animal biobank Multi-disciplinary read-outs (including clinical and pathology scoring, and medical imaging via MRI, X-ray, and endoscopy) Druggability assessment …Read More >

We offer an extensive panel of inflammatory bowel disease models in mice and rats, including genetically modified, chemically induced, and adoptive transfer-related IBD models. Let our experts help you choose the best IBD animal models to advance your research programs. Learn more about our platform of inflammation models  

This webinar will focus on aspects related to PROTAC discovery and chemistry workflows, such as ligand finding strategies, synthesis optimization, and linker design. Successful development of bifunctional molecules requires a deep understanding of multiple processes, including biophysical events which dictate induced proximity and how technologies such as DNA-encoded libraries (DEL) can be leveraged to identify …Read More >

This webinar will focus on PROTAC biology workflows, such as in vitro screening assays, in vivo testing, and optimization of DMPK properties. Topics will include the best use of biochemical assays to measure binary/ternary complex formation, cell-based assays to assess target engagement and degradation, strategies for enhancing drug delivery and formulation, and PK/PD evaluation of …Read More >

This week’s episode of our “How Does It Work?” series features Peptide-Oligonucleotide Conjugates. Peptide-oligonucleotide conjugates are made up of peptide and oligonucleotide components. These cutting-edge molecules have many applications in biomedicine. The oligonucleotide component can interact with mRNA to alter gene expression within diseased cells but oligonucleotides are easily degraded in the body and have …Read More >