Knowledge Library
Recognition of NIS1 by BRI1-Associated Receptor Kinase 1
The safe production of cultivated plants is threatened by various fungal diseases. NIS1 is a secreted effector protein produced by various fungal pathogens. BAK1 is a plant receptor-like kinase that plays a crucial role in recognizing pathogen-associated molecules like NIS1. Understanding the interaction between NIS1 and BAK1 is important for studying plant defense mechanisms against …Read More >
Discovery of SARS-CoV-2 Papain-like Protease Inhibitors
SARS-CoV-2 antivirals which have been clinically approved or are in late-stage development are directed against either the RNA-dependent RNA polymerase (RdRp) or the main protease (Mpro). With the possibility of resistance developing over time, there is a need for additional oral antivirals directed against currently undrugged viral targets. Conserved across coronaviruses, the SARS-CoV-2 papain-like protease …Read More >
One Stop Target-to-Hit Platform: p53
TP53 is the most frequently mutated tumor suppressor gene in human cancer. Mutant p53 proteins not only lose wild-type p53-dependent tumor suppressive functions, but also frequently acquire oncogenic gain-of-functions that promote tumorigenesis. Small molecules that can either protect p53 from negative regulators or restore the functionality of mutant p53 proteins are gaining interest, and potential drugs …Read More >
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
The contribution of the X-ray crystallography team from our WuXi AppTec site in Germany was acknowledged in a recent study published in the journal Cancer Discovery. In this study, the authors show that compound STX-478, an allosteric PI3Kα inhibitor, selectively targets prevalent PI3Kα helical- and kinase-domain mutant tumors. STX-478 demonstrated robust efficacy in human tumor …Read More >
Cryo-EM
We offer established protocols for cryo-EM structure determination, with extensive experience in epitope mapping, formulation characterization, and structure-based drug discovery (SBDD). Our integrated services platform also includes: Biophysical and biochemical screening assays Crystal-grade protein production High-resolution X-ray crystallography
High Throughput Protein Production
We offer high-quality protein production with expertise across all major target classes. Our panel of services includes an automated multistep purification platform for fast parallelized production of high quality proteins, and QC/functionality testing via nanoDSF and MST techniques.
