Despite the resurgence of interest in peptide therapeutics for historically “undruggable” targets, de novo discovery of peptide ligands remains a challenge.  Unlike traditional technologies, DNA-encoded libraries (DELs) predominantly employ unnatural amino acids, and the resulting cyclic peptide-like molecules which are generated display a wider range of chemical space and smaller ring sizes with improved physicochemical …Read More >

A new wave of drugs that achieves targeted delivery of radioisotopes is rapidly gaining momentum.  As the discovery pipeline widens and new drug approvals increase, the field is expanding and becoming more diverse in the strategies employed to deliver cell-killing radioisotopes. One area that is showing considerable promise is the incorporation of an isotope-chelating moiety …Read More >