Knowledge Library

In Vivo Pharmacology for Ophthalmic Drug Development

Introduction The number of people with vision impairment has increased due to the continuously expanding and aging population, as well as lifestyle changes. According to the Lancet Global Health, by 2050, myopia is expected to affect 5 billion people. Additionally, the number of individuals with distance vision impairment is projected to reach 895 million, including …Read More >

Resource Type: Article, Blog
Resource Topic: in vivo Pharmacology

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Advances and Biological Evaluation of Diabetes Drugs

Introduction: Diabetes is a chronic, metabolic disease resulting from defects in insulin secretion and varying degrees of insulin resistance. Early symptoms include increased thirst and urination, increased hunger, and blurred vision. Progressively, complications such as cardiovascular disease, peripheral neuropathy, nerve damage, myocardial disease, and kidney disease may occur. The prevalence of diabetes at younger ages …Read More >

Resource Type: Article, Blog
Resource Topic: Biochemical Assays, in vitro biology, Metabolic Diseases

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OncoWuXi Express: Efficacy of DLL3 CAR-T in SHP-77 Tumor Models

OncoWuXi Express: Evaluation of DLL3 CAR-T in SHP-77-Luc Tumor Models  Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we showcase our DLL3 CAR-T cell preparation and evaluation of their anti-tumor …Read More >

Resource Type: Article, Blog
Resource Topic: CAR-T Cell, Oncology, Tumor Models

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Accelerating GPCR Drug Discovery and Development

GPCRs: Function, Structure, and Classifications G protein-coupled receptors (GPCRs) are a prevalent class of transmembrane proteins in animal cells, representing one of the largest families of membrane proteins in mammals. These receptors are widely distributed across numerous organs and regulate physiological functions by stimulating intracellular signaling pathways, thereby influencing cellular behavior. GPCRs have a central …Read More >

Resource Type: Article, Blog
Resource Topic: Biochemical Assays, Cell-based Assays, Hit-to-Lead, in vitro biology

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OncoWuXi Express: Paclitaxel-Induced Resistant Tumor Models

Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you the newly established paclitaxel resistant HGC27 and HCC1806 tumor models. https://onco.wuxiapptec.com Paclitaxel, known for its …Read More >

Resource Type: Article, Blog
Resource Topic: Oncology, Tumor Models

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Precocious Puberty Animal Models

Leveraging Precocious Puberty Animal Models for Preclinical Research Precocious puberty, one of the frequently observed conditions in pediatric endocrinology, significantly impacts the physiological, psychological, and long-term health of children. Moreover, this disorder is associated with increased risks of various diseases [1]. Precocious puberty is an endocrine disorder caused by abnormal secretion of sex hormones. It …Read More >

Resource Type: Article, Blog
Resource Topic: in vivo Pharmacology

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Expanded Role of PDX Models in Anticancer Drug Development

Expanded Role of PDX Models in Anticancer Drug Development Patient-derived xenograft (PDX) models are established by implanting surgically resected patient tumor tissues into immunodeficient mice and have become a pivotal tool in preclinical cancer research due to high clinical-relevance. These models faithfully preserve the original tumor’s molecular, histopathological and pharmacological characteristics, reflecting the heterogeneity and …Read More >

Resource Type: Article, Blog
Resource Topic: Oncology, Tumor Models

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OncoWuXi Express: AAI 2024 Posters: Sneak Peek

OncoWuXi Express| Immunology 2024™ Poster Sneak Peek Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you the highlights of posters we will present at …Read More >

Resource Type: Article, Blog
Resource Topic: Immunology

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OncoWuXi Express: PSMA Overexpressing PC3 Tumor Model

Introduction: OncoWuXi Express will continue to keep you informed about updates to our on-line tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you the newly established PSMA-overexpressing PC3 prostate cancer model. https://onco.wuxiapptec.com Globally, prostate cancer stands not only …Read More >

Resource Type: Article, Blog
Resource Topic: Oncology, Tumor Models

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Resource Topics
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