Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads, show great potential as cancer therapies.  However, primary and secondary resistance is frequently observed.  The successful development of next generation ADCs necessitates the establishment of tumor models that address the mechanism of action underlying this resistance. At the 2025 Festival …Read More >

Gout is a common type of inflammatory arthritis caused by elevated uric acid levels in the blood. When uric acid levels are too high, monosodium urate (MSU) crystals can form in the body, especially in and around joints. These MSU crystals are sharp and can cause inflammation when they are deposited in the joints, leading …Read More >

In our latest publication, WuXi AppTec scientists introduce two new methods that utilize readily accessible aldehydes to create substituted isoxazolines and isoxazoles by the 1,3-dipolar cycloaddition reaction. Isoxazoles and isoxazolines, known for their diverse bioactivities—including antibacterial, antifungal, and insecticidal properties—are now accessible through a novel DNA-compatible method developed in this study. This approach enables the …Read More >

From April 25 to 30, 2025, the annual meeting of the American Association for Cancer Research (AACR), one of the largest and longest-standing cancer research conferences in the world, will be held in Chicago. At this year’s AACR meeting, WuXi Biology has been selected to present several posters detailing latest scientific insights, covering a range …Read More >

At this year’s annual meeting of the American Association for Cancer Research (AACR), WuXi Biology has been selected to present multiple posters detailing latest scientific insights, covering a range of cutting-edge topics from preclinical tumor model development and biomarker discovery, to the evaluation of novel anti-cancer therapies. Explore this quick overview of WuXi Biology’s pioneering …Read More >

From Pathogenesis to Therapeutic Innovations Introduction: Membranous nephropathy (MN) has received particular attention among autoimmune kidney disease due to its distinct pathophysiology and clinical manifestations. Unlike other autoimmune nephropathies, MN is primarily driven by pathogenic autoantibodies that activate immune cells, leading to oxidative stress and inflammatory responses that compromise the glomerular filtration barrier [1, 2]. …Read More >

Systemic sclerosis (also known as scleroderma) is a chronic autoimmune disease that leads to the buildup of scar tissue in various internal organs, as well as the skin. Fibrosis is a key feature of systemic sclerosis, where uncontrolled production of collagen and other extracellular matrix proteins by fibroblasts leads to excess connective tissue accumulation. This …Read More >

Synthetic lethality, where combining two non-lethal mutations results in cell death, is exploited in cancer therapy, with PARP inhibitors like olaparib targeting BRCA-deficient cells by exploiting this interaction.  Werner syndrome helicase (WRN) is a synthetic lethal target in cancers with microsatellite instability due to impaired DNA mismatch repair.  WRN is synthetically lethal with MLH1, a …Read More >

Polycythemia vera (PV) is a chronic myeloproliferative disorder, a type of blood cancer characterized by the overproduction of red blood cells (erythrocytosis) which can lead to thicker blood and an increased risk of blood clot.  Most cases of PV are caused by a point mutation in the JAK2 gene (JAK2-V617F). To support drug discovery teams …Read More >