Affinity Selection Mass Spectrometry
Our dedicated ASMS (Affinity Selection Mass Spectrometry) screening team offers clients this unique platform for the identification of small molecules capable of binding to the active sites of target proteins. These active small molecules will be the perfect starting point for your drug discovery programs. Our high-quality service supports new modalities and challenging targets in drug discovery, including:
- Disrupting protein-protein interactions (PPI)
- Molecular glues
- Chemically induced proximity (CIP)
- Membrane proteins
- Transcription factors
- RNA
Our service is backed by access to small molecule libraries, automated operational systems, sensitive high-resolution mass spectrometry devices and efficient data processing software.
Access our mini poster and read about our case study, “Application of ASMS for Molecular Glue Discovery, Targeting the CDK12/CCNK/DDB1 Complex” by clicking HERE
Access our mini poster and read about our case study, “Adaptable Screening on Membrane Protein GLUT1 using ASMS” by clicking HERE
ASMS Principle
ASMS Screening Workflow at WuXiAppTec
Why do you need ASMS?
WuXi AppTec Compound Library for ASMS (270 K)
Library features
- Optimized diversity to maximize chemical space coverage
- WuXi AppTec and Commercial sources
Filtered by
- Pan Assay Interference Compounds (PAINS)
- WuXi AppTec structural filters, derived from medicinal chemistry expertise
Drug-like property distribution
- MW 200 ~ 500
- logP 0 ~ 5
- Hydrogen bond donors 0 ~ 5
- Hydrogen bond acceptors 0 ~ 10
- Formal charge -2 ~ 2
- Number of rotatable bonds 0 ~ 9
- PSA 10 ~ 150
- Number of heavy atoms 15 ~ 35
Physicochemical property distribution
Compound Sources
Chemical space comparison
Comprehensive Capability and Strengths at WuXi AppTec
