THERAPEUTIC AREAS Archives

Stress Model for Antidepressant Drug Discovery

Stress is a major environmental risk factor that triggers depressive episodes, inducing symptoms such as anhedonia, negative cognitive bias, and...

Supporting Discovery of mRNA Drugs

Unlike conventional protein-targeted therapies, which often provide only transient effects, nucleic acid therapeutics have the potential for long-lasting effects and...

Advanced Conjugate Delivery Systems for Oligonucleotides

Oligonucleotide therapeutics represent a transformative treatment modality with demonstrated potential across metabolic disorders, CNS diseases, muscular dystrophies, and a broad...

Efficacy of Biologics in Humanized Mouse Models for IBD

Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn’s disease, is a chronic, immune-mediated disorder characterized by persistent inflammation...

Psoriasis: Pathogenesis, Treatment, and Evolving Disease Models

Introduction: Autoimmune skin diseases (AISDs) are a group of chronic inflammatory disorders characterized by the immune system mistakenly recognizing self-antigens...

CTHRC1 as a Novel Candidate for Neurodevelopmental Disorders

Cognitive dysfunction affects over 50 million individuals worldwide, with Alzheimer’s disease (AD) representing two-thirds of cases. Due to the complexity...

mTOR Inhibition Enhances Targeted Protein Degradation Efficacy

Targeted protein degradation (TPD) approaches, including molecular glue degraders (MGDs) and proteolysis targeting chimeras (PROTACs), can overcome traditional occupancy-based inhibitor...