Targeted Protein Degradation Archives

Application of On-bead DEL Technology in Target Protein Degradation Phenotypic Screen

DNA-encoded library (DEL) technology has been recognized as a major screening method, offering unique advantages through its ability to provide...

Strategies for Advancing Molecular Glue Drug Discovery

In this webinar, WuXi Biology scientists showcase our end-to-end molecular glue discovery platform. Molecular glues act as “molecular adhesives”, facilitating...

Key Steps in Validating Targeted Protein Degraders

Choose excellence, choose WuXi Biology – your reliable partner in Targeted Protein Degradation (TPD) drug discovery. Since 2016, we have...

Targeted Protein Degraders: Trends, Challenges, and Solutions

Since 2016, WuXi AppTec has built a comprehensive discovery platform focused on Targeted Protein Degraders (TPDs). Our platform enables research...

Rational Design and Optimization of a Potent IDO1 PROTAC

Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that metabolizes tryptophan, and its activity can lead to immunosuppression, thereby allowing tumors...

Advanced On-bead DEL Technology for Enhanced Drug Discovery Screening

DNA-encoded library (DEL) technology has been recognized as a major screening method with unique advantages for offering vast chemical diversity...

Accelerating CIP Discovery with ASMS and DEL

Chemical inducers of proximity (CIPs) are small molecules that induce the proximity of two biological targets, usually proteins. Molecular glues...

Molecular Glues Discovery: Challenges and Opportunities

Introduction: Molecular glues (MGs) are a class of small molecules that alter the surface properties of proteins to strengthen or...

Targeted Protein Degradation Platform

Targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular...

Knowledge Library