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Engineered Oncolytic Viruses Expressing Immunomodulatory Genes Enhances In Vitro Anti-Tumor Cellular Immune Responses

While chemo- and radio-therapy are considered the first-line of treatment for most cancers, its serious side effects have led to continuous innovation and discovery of new anti-tumor treatments. Oncolytic viruses (OVs) possess a magnitude of mechanism of action to elicit anti-tumor immune response, including OVs innate cytotoxicity and enhanced anti-tumor immunity by inserting immunomodulatory genes. …Read More >
Resource Type: Latest Science Poster
Resource Topic: Biomarkers Cell-based Assays Immunology in vitro biology Oncology Oncolytic Viruses Phenotypic Assays Target Identification and Validation

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond
Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Development of an integrated in vitro and in vivo OVA-specific system for cancer vaccine discovery
Resource Type: Poster
Resource Topic: Biomarkers Cell-based Assays Immunology in vitro biology Lead Optimization Oncology Target Identification and Validation Target-Specific Assays Tumor Models

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Establishment of spatial transcriptomics assay to find the mechanism of immune therapy against tumors
Resource Type: Poster
Resource Topic: Biomarkers Immunology Oncology Target Identification and Validation Tumor Models

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Evaluating cancer therapies combining radiotherapy with immunotherapy or inhibitors of the DNA damage response
Resource Type: Poster
Resource Topic: Cell-based Assays Immunology in vitro biology Oncology Tumor Models

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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
Resource Type: Publication
Resource Topic: Antibodies CRISPR/Cas9 Immunology Oncology Screening Libraries Target Identification and Validation Target-Specific Assays Tumor Models

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Evaluation of the efficacy of ADC in vitro and in vivo

Abstract Antibody drug conjugate (ADC) is a promising complex with therapeutic potential that aimed to the treatment of solid tumor and hematological malignancies. Compared with the therapeutic monoclonal antibody, ADCs-derived monoclonal antibody is conjugated with cytotoxic agents which can deliver potent cellular toxins to targeted cancer cells specifically. According to the specialization of ADCs, we …Read More >
Resource Type: Poster
Resource Topic: Antibody Drug Conjugate Biochemical Assays Biomarkers Cell-based Assays Immunology in vitro biology Lead Optimization Oncology Tumor Models

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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
Resource Type: Publication
Resource Topic: Antibodies Biomarkers Cells and Protein Science CRISPR/Cas9 Immunology Oncology Screening Libraries Target Identification and Validation Target-Specific Assays Tumor Models

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Cancer Immunotherapy and the Application of In Vitro Immunoassays in Drug Development
Resource Type: Webinar
Resource Topic: Antibodies Autoimmune and Inflammatory Diseases Biochemical Assays Cell-based Assays Hit-to-Lead Immunology Lead Optimization Oncology Phenotypic Assays Small Molecules Target Identification and Validation Target-Specific Assays

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