Knowledge Library

Development of NK Humanized Mouse Models

Natural killer (NK) cells play a crucial role in the immune system and can recognize and kill cancer cells. Research in this area is focused on strategies for enhancing NK cell activity in tumor immunotherapy. These strategies include using monoclonal and multi-specific antibodies, as well as immune modulator molecules like cytokines, to redirect and stimulate …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Immunology, in vivo Pharmacology, Oncology, Tumor Models

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OncoWuXi Express: Evaluation of T Cell Engagers

Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you our preclinical pharmacological evaluation platform for T cell engagers. https://onco.wuxiapptec.com Introduction T-cell engagers (TCEs) are …Read More >

Resource Type: Article, Blog
Resource Topic: Immunology, in vivo Pharmacology, Oncology

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How Peptide Vaccines are Reshaping Cancer Immunotherapy

Research on cancer immunotherapy has firmly established immune cells as key players in effective cancer treatment. Peptide vaccines directly targeting immune cells have demonstrated immense potential due to their specificity and applicability, but developing peptide vaccines to generate tumor-reactive T cells remains challenging. WuXi AppTec contributed to a review article discussing various elements of effective …Read More >

Resource Type: Article, Latest Science, Publication
Resource Topic: Immunology, Oncology, Peptides

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OncoWuXi Express: Efficacy of JAK Inhibitors in a Type II Collagen-induced Arthritis Model

Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we present an evaluation of the efficacy of different JAK subtype inhibitors in a Type II collagen-induced arthritis model, along with corresponding …Read More >

Resource Type: Article, Blog
Resource Topic: Autoimmune and Inflammatory Diseases, Immunology, in vivo Pharmacology

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mRNA-Encoded Modulators Suppress Tumor Growth

Unlike conventional protein-targeted therapies, nucleic acid therapeutics have the potential for long-lasting effects and greater target specificity. WuXi AppTec provides a comprehensive platform to support the discovery of mRNA drugs.  Our services include mRNA design and production, assessment of mRNA delivery systems, in vitro evaluation, and determination of in vivo efficacy and biodistribution. At AACR …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Immunology, in vivo Pharmacology, Oligonucleotides, Oncology

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Rapamycin Ameliorates Renal Pathology in a Model of Passive Heymann Nephritis

Passive Heymann nephritis, induced by intravenous injection of anti-Fx1A in susceptible rat strains, is a complement-dependent model of glomerular disease that resembles membranous nephropathy in humans.  At IMMUNOLOGY2024, WuXi AppTec presented a poster demonstrating that rapamycin exerts a protective effect against anti-Fx1A-induced passive Heymann nephritis by reducing proteinuria.  The authors show that this antiproteinuric effect …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Immunology, in vivo Pharmacology

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NK Cell Humanized Tumor Models

NK cells are effector innate lymphoid cells (ILCs) that do not require antigen-specific priming. NK cells are not only killer cells that help to suppress tumors, but also are involved in the generation and maintenance of adaptive immune responses.  The process of antibody-dependent cell-mediated cytotoxicity (ADCC) makes use of innate immune cells which provide antitumor …Read More >

Resource Type: Latest Science, Presentation
Resource Topic: Immunology, Oncology, Tumor Models

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Poster Presentations at IMMUNOLOGY2024

Join WuXi AppTec at IMMUNOLOGY2024™. For this year’s annual meeting of the American Association of Immunologists (AAI), WuXi Biology has been selected to present five noteworthy posters, showcasing our panel of preclinical models representing urticaria, nephritis, rheumatoid arthritis, gout, and atopic dermatitis. Stop by Booth 777 to get your questions answered by one of our …Read More >

Resource Type: Video
Resource Topic: Immunology, in vivo Pharmacology

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OncoWuXi Express: AAI 2024 Posters: Sneak Peek

OncoWuXi Express| Immunology 2024™ Poster Sneak Peek Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you the highlights of posters we will present at …Read More >

Resource Type: Article, Blog
Resource Topic: Immunology

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Resource Topics
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