mRNA-Encoded Modulators Suppress Tumor Growth

Unlike conventional protein-targeted therapies, nucleic acid therapeutics have the potential for long-lasting effects and greater target specificity.

WuXi AppTec provides a comprehensive platform to support the discovery of mRNA drugs. Our services include mRNA design and production, assessment of mRNA delivery systems, in vitro evaluation, and determination of in vivo efficacy and biodistribution.

At AACR 2024, WuXi AppTec presented a poster showcasing the anti-tumor properties of mRNA-encoded CD3-EpCAM bispecific antibody (BsAb) and mRNA-encoded IL-12 protein. The results showed that these two mRNAs exhibited anti-tumor activity and activated immune cells both in vitro and in vivo.