Knowledge Library
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase
Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low...
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Meeting Neurodegenerative Disease Head-On with Emerging Drug Discovery Strategies
Chronic neurodegenerative diseases encompass a variety of progressive conditions that affect neurons, including Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, and...
Continue Reading One-Stop Target-to-Hit Solutions
WuXi AppTec | Target-to-Hit Solutions Protein Production | All Target Classes and Challenging Proteins Biophysical & Biochemical Platforms | Ready-To-Go...
Continue Reading DELpro: A New Method of Hit Discovery
DNA-Encoded Library (DEL) technology involves a novel affinity selection process that integrates chemistry, biology, bioinformatics and computational chemistry to facilitate...
Continue Reading Validation of GVHD in mouse model for preclinical efficacy screen
AACR Annual meeting 2021 Na Xu, Ya Zhang, Rou Xie, Lijun Jia, Yingying Cai, Qing Lin Oncology and Immunology Unit,...
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