Knowledge Library

Discovery of RNA binding molecule using DNA-encoded library technology

Resource Type: Webinar
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

VIEW

Validation of GVHD in mouse model for preclinical efficacy screen

AACR Annual meeting 2021 Na Xu, Ya Zhang, Rou Xie, Lijun Jia, Yingying Cai, Qing Lin Oncology and Immunology Unit, WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Background Bone marrow transplantation has been successfully and widely used to treat diseases such as leukemia and lymphomas. However, the complication Graft …Read More >

Resource Type: Poster
Resource Topic: Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Chemical Biology and Proteomics in vivo Pharmacology Oncology Tumor Models

VIEW

Empowering Organic Syntheses with Quantum Mechanics Analyses

Syntheses of specifically functionalized molecules continue to be rate limiting steps (RLS) in drug discovery. Improvement in this RLS means investing only in reactions/synthetic sequences that are more likely to succeed. Structural diversifications, different substitution patterns or unique heterocyclic systems can often adversely impact the crucial step(s) of established synthetic sequences or development of feasible …Read More >

Resource Type: Article
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead in silico services Lead Optimization Quantum Mechanics Small Molecules

VIEW

The Synthesis of an Entrepreneur: Merging a Passion for Biochemistry, Synthetic Chemistry, and Bioactive Molecules in Academia

INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) Synthetic chemist Joseph Ready believes a huge amount of innovation in the drug industry comes from academia. Academic science is arguably the greatest source of innovation in our ecosystem, yet faces challenges when considering the transition from the lab to early stage …Read More >

Resource Type: Article
Resource Topic: Central Nervous System & Pain Chemical Biology and Proteomics Discovery Chemistry High-throughput screening (HTS) Hit-to-Lead Infectious Diseases Lead Optimization Oncology Small Molecules Target Identification and Validation

VIEW

Drug Hunter: Discovering New Frontiers in Cancer Treatments & Beyond

INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) As a self-proclaimed drug hunter, Phil Jones is on a mission to identify the next generation of cancer medicines that improve the lives of patients with cancer. He leads a multi-disciplinary team of scientists at The University of Texas MD Anderson Cancer Center’s Institute …Read More >

Resource Type: Article
Resource Topic: Biomarkers CAR-T Cell Cells and Protein Science Chemical Biology and Proteomics DRUG DISCOVERY AND INNOVATION Hit Finding in vitro biology in vivo Pharmacology Oncology Phenotypic Assays Small Molecules Target Identification and Validation

VIEW

Targeted Protein Degradation Platform

BIOLOGY & PHARMACOLOGY BINARY/TERNARY COMPLEX FORMATION Biochemical & Biophysical Assays Biochemical binding assay Cellular Assays TARGET UBIQUITINATION & DEGRADATION In vitro Assays-Target ubiquitination Target degradation assay PK/PD Animal Disease Model Evaluation CHEMISTRY Specific virtual library design Compound synthesis Conjugation and all type of custom syntheses from milligram to kilogram scale Purification and analytical support on …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays Biomarkers Biophysical Assays Cell-based Assays Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead in vitro biology in vivo Pharmacology Lead Optimization Small Molecules Targeted Protein Degradation

VIEW

DEL Screening – DELight Handbook

DEL Screening | WuXi AppTec DELight Kit  Faster and Lighter Drug Discovery DELight kit containing 58 libraries and 10.8 billion compounds, buffers and a step-by-step online experimental manual. Drug developers perform affinity selection according to the manual and return the sample to WuXi AppTec upon completion.

Resource Type: Brochure
Resource Topic: Chemical Biology and Proteomics DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation Targeted Protein Degradation

VIEW

Discovery Chemistry Outsourcing Services

Global Leader in Discovery Chemistry Outsourcing Services Based on FTE (Full Time Equivalent) Model | Customization to Client’s Synthetic Chemistry with high productivity, quality, speed, and reliability Project Management:  we manage project timelines and compound flow Medicinal Chemistry: we provide compound design and project management Integrated Projects from targets to hits to leads to preclinical …Read More >

Resource Type: Brochure
Resource Topic: Candidate Selection Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead Lead Optimization Mass Spectrometry-based Assays Quantum Mechanics Small Molecules

VIEW

Translational Oncology

Biomarker discovery Mouse clinical trial 61 PDX-derived primary cancer cell lines Drug-resistant xenograft models Combination therapy platform including radiation World leading genome sequencing and bioinformatics capability

Resource Type: Brochure
Resource Topic: Biomarkers Candidate Selection Cell-based Assays Cells and Protein Science Chemical Biology and Proteomics Lead Optimization Oncology Phenotypic Assays Tumor Models

VIEW


Resource Topics
× peptide, amino acid

Contact An Expert Today!