Latest Science Archives - Page 6 of 8

Precision-Cut Tissue Slices to Advance Drug Discovery

Precision-cut tissue slices (PCTS) are an effective ex vivo model for studying human diseases, including those involving the tissue microenvironment....

Novel ROR1 Antibody with High Specificity and Sensitivity for Predictive Biomarker Detection

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a key mediator of non-canonical Wnt signaling and plays a critical role...

Development of NK Humanized Mouse Models

Natural killer (NK) cells play a crucial role in the immune system and can recognize and kill cancer cells. Research...

Isogeneic Trop-2 Model for Evaluating Anti-Trop-2 ADCs

Antibody-Drug Conjugates (ADCs) have made significant advancements in cancer treatment, particularly for solid tumors. The bystander effect of ADCs, where...

HPV18-Related Cancer Model Development

Cancers, like cervical cancer and head & neck cancer, are strongly linked to human papillomavirus (HPV) infection. Targeting the HPV...

Development of Novel ADC-Resistant Models

Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads, show great potential as cancer...

Developing Animal Gout Models

Gout is a common type of inflammatory arthritis caused by elevated uric acid levels in the blood. When uric acid...

DNA-Compatible Huisgen Cycloaddition

In our latest publication, WuXi AppTec scientists introduce two new methods that utilize readily accessible aldehydes to create substituted isoxazolines...

Platform Supporting the Discovery of Agents against HSV

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are globally prevalent human pathogens associated with a wide range of...