Therapeutic Potential of Polatuzumab Vedotin for the Treatment of DLBCL
Approximately 20-40% of diffuse large B-cell lymphoma (DLBCL) patients experience relapsed or refractory disease after initial treatment with R-CHOP (a...
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Developing Resistant Models to Diverse ADC Drugs
Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads, show great potential as cancer...
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Advanced On-bead DEL Technology for Enhanced Drug Discovery Screening
DNA-encoded library (DEL) technology has been recognized as a major screening method with unique advantages for offering vast chemical diversity...
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Accelerating CIP Discovery with ASMS and DEL
Chemical inducers of proximity (CIPs) are small molecules that induce the proximity of two biological targets, usually proteins. Molecular glues...
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Discovery of a Novel Covalent Inhibitor Using DEL
With advancements in drug design, there is resurging interest in drugs that form covalent bonds with their targets. Covalent drugs...
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DEL Screening to Discover Small Molecule Ligands for RNA
RNA-targeted therapeutics are highly intriguing due to their unique physiological properties and novel modes of action in drug R&D. Developing...
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