Novel ROR1 Antibody with High Specificity and Sensitivity for Predictive Biomarker Detection

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a key mediator of non-canonical Wnt signaling and plays a critical role in cancer progression. ROR1 is selectively and highly expressed in various solid tumors and hematological malignancies, while absent in normal adult tissue, making it a promising target for cancer therapy. Currently, there is a need for more effective immunohistochemical tools that are sensitive enough to detect ROR1 in patient tumor samples.

At AACR 2025, WuXi Biology presented a poster describing the in-house development of a recombinant rabbit monoclonal antibody which demonstrates superior sensitivity and specificity for ROR1 (across multiple methodologies) compared to existing antibodies.  The results shown here support the use of this antibody as a reliable tool for clinical biomarker detection, potentially advancing ROR1-targeted cancer treatment.

AACR 2025 Poster_Novel ROR1 Antibody for Predictive Biomarker Detection

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