Resources Archive - Page 16 of 48

Discovery of Potent, Selective, and Orally Available IRE1 alpha Inhibitors

Inositol-requiring enzyme 1α (IRE1α) is a sensor protein that plays a key role in multiple myeloma (MM) and is a...

Oncogenic Virus-associated Tumor Models

Viruses have well-established causal roles in numerous human cancers. Approximately 10% of cancers globally are attributed to viral infections, primarily...

Discovery of SARS-CoV-2 Papain-like Protease Inhibitors

SARS-CoV-2 antivirals which have been clinically approved or are in late-stage development are directed against either the RNA-dependent RNA polymerase...

Pulmonary Disease Platform

WuXi AppTec offers a comprehensive platform of services for pulmonary disease-related research. Our panel of validated disease models covers pulmonary...

Fragment-based Drug Discovery

Fragment-based drug discovery is one of the most well-developed approaches for projects starting from small, low-affinity compounds. Powerful biophysical and...

Fibroblast Growth Factor Receptors

Fibroblast growth factor receptor (FGFR) signaling pathways represent promising targets for therapeutics owing to their role in development, tissue, and...

Novel DEL Hit That Binds in the Cbl-b SH2 Domain

Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, is a key regulator of T cell activation and plays...

OncoWuXi Express: Comprehensive PDX Panel Service for Drug Discovery

OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well...

Research Strategies for the Discovery of Targeted Protein Degraders

In this webinar, experts present research strategies for the discovery of targeted protein degraders. Over the past decade, targeted protein degradation...

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