Knowledge Library
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors
Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) have emerged as key regulators of neuronal degeneration and axon growth. WuXi AppTec scientists recently contributed to a research article in the Journal of Medicinal Chemistry demonstrating the use of ligand- and structure-based drug design approaches to discover an amino-pyrazine chemical series of DLK and …Read More >
Case Study: DEL Data Combined with In Silico Deep-Learning Model
Read our newest case study on enhancing predictivity of drug-target interactions. In collaboration with Cyclica, WuXi AppTec scientists engaged in a study to understand the synergies between DNA encoded library (DEL) screening and Cyclica’s MatchMaker™ deep-learning model for protein-ligand interactions. Our findings indicate that combining experimental DEL data with computational analysis from MatchMaker™ can lead …Read More >
NLRP3 Services Platform
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DNA-Encoded Libraries: DELopen Handbook
DNA-Encoded Libraries: DELopen User Manual
DNA Encoded Libraries: DELopen Flyer
XPRESS Portfolio: Off-the-Shelf Crystallography
XPRESS Portfolio Over 150 targets enabled for off-the-shelf crystallography Broad range of targets and classes Established protocols for protein production and crystallization Average turn-around time of 2 months