Resources Archive - Page 14 of 48

OncoWuXi Express: Pancreatitis Animal Models

OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well...

PRMT5 Related Tumor Models

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as glioblastoma represents a potentially targetable vulnerability. MTAP deletions occur in...

Targeted Protein Degradation Platform

Targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular...

Streamlining Gene Therapy with AAVs

Gene therapies are enabling a rapid expansion in the scope of treatable disease. Adeno-associated viruses (AAVs) are particularly advantageous delivery...

Developing Novel AR Mutant Prostate Cancer Models

Since prostate cancer heavily depends on androgen hormones for growth, targeting the androgen receptor (AR) signaling pathway is a key...

Toxicology Profile of a Novel GLP-1 Receptor Agonist

Glucagon‐like peptide‐1 (GLP-1) receptor agonists have emerged as promising therapeutic options for addressing type‐2 diabetes, obesity, and related conditions. However,...

Strategies for Screening and Characterizing Targeted Covalent Inhibitors

With advancements in drug design, there is resurging interest in drugs that form covalent bonds with their targets, often referred...

Discovery of a Specific CKIP-1 Ligand using DEL

Casein kinase 2-interacting protein-1 (CKIP-1) performs a critical negative role in the regulation of bone formation. Accumulated evidence strongly supports...

Application of Affinity Selection Mass Spectrometry: Membrane Proteins

Introduction Membrane proteins are essential for various cellular processes, including energy conversion, signal transduction, and disease progression. Efficient and accurate...

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