Targeted Protein Degradation Platform

Targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular self-destruction mechanisms. This technology is enabling researchers to pursue targets that were previously considered undruggable and to address the resistance issue of small molecule inhibitors.

Since 2016, WuXi AppTec has built a comprehensive TPD discovery service platform to investigate the full functional cycle of protein degraders – from binary/ternary complex formation to target ubiquitination and degradation.  At the 7^th Annual TPD & Induced Proximity Summit, we presented a poster demonstrating the capabilities of our TPD platform, highlighting TPD research strategies through relevant case studies.

Poster_TPD and Induced Proximity Summit

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