Resources Archive - Page 12 of 48

Women’s Health Platform

Women’s health care is crucial not only for the well-being of individual women but also for the health and prosperity...

Comprehensive Fibrosis Drug Development Platform

Introduction: Fibrosis is a pathological process characterized by the excessive deposition of extracellular matrix (ECM) within an organ, leading to...

Targeting FAK Improves the Tumor Uptake of ADCs

Antibody-drug conjugates (ADCs), exemplified by HER2-targeted Enhertu and TROP2-targeted Trodelvy, have demonstrated significant therapeutic potential in cancers. However, a subset...

Strategies to Accelerate the Development of Antibody-Drug Conjugates

Antibody-drug conjugates (ADCs) hold great promise as targeted cancer therapeutics, but their complex structure poses significant development and safety challenges...

BRCA2 Deficient DLD-1 Model

BRCA1 and BRCA2 proteins are key components of the homologous recombination repair pathway for repairing double-stranded DNA breaks. Mutations in...

Discovery of a Selective BET Inhibitor for Treating Osteoarthritis

Bromodomain and extra-terminal domain (BET) family proteins are key regulators of gene transcription and have been implicated in a wide...

Cyclin Dependent Kinases: Structural Biology Services

Cyclin-dependent kinases (CDKs) and their cyclin regulatory subunits form complexes that are essential for driving abnormal growth processes in cancer...

STAT Family: Structural Biology Services

Signal transducer and activator of transcription (STAT) proteins are key mediators of cellular immunity, proliferation, apoptosis, and differentiation. STATs are...

Production and Characterization of Protein Biologics

At the 2024 Protein & Antibody Engineering Summit (PEGS) Europe, Crelux presented a poster highlighting its drug discovery platform for...

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