Severe Hyperglycemia and Hyperlipidemia Alter Tumor Growth and Immune Profiles in Syngeneic Tumor Models

Studies have demonstrated that obesity can promote cancer progression through mechanisms that include chronic low-grade inflammation.  Previous research with diet-induced obese animal models revealed that T cells in colorectal cancer are reduced in obesity. However, it is unclear how the tumor microenvironment changes under severe hyperglycemia and hyperlipidemia in different cancers.

At AACR 2025, HD Biosciences, a WuXi AppTec company, presented a poster highlighting the changes in the immune cell population in syngeneic tumor-bearing mice with MC38 colorectal cancer in genetically obese models characterized by severe hyperglycemia and hyperlipidemia.  The authors show that MC38 colorectal cancer grows faster in db/db mice with severe hyperglycemia and hyperlipidemia than in the WT C57BL6 mice. RNA profiling revealed that the gene expression profile in the tumor favors tumor expansion, and FACS analysis of the tumor-infiltrated lymphocytes showed more exhausted T cells and less granzyme B expression in myeloid cells in db/db mice.

AACR 2025 Poster_Severe Hyperglycemia and Hyperlipidemia Alter Tumor Growth and Immune Profiles in Syngeneic Models

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