DEL and Display for de novo Peptide Discovery
Peptide DEL
Peptide DEL combine the vast chemical diversity of peptides with the high-throughput screening power of DNA-Encoded Libraries (billions in one test). Each peptide is tagged with a unique DNA barcode, enabling rapid identification of hits against biological targets. WuXi Biology, with years of experience in DEL end-to-end solutions, offers diverse peptide DEL libraries, selection services and synthesis to in vitro validation.
Features
- High backbone and side chain diversity
- Incorporation of abundant unnatural AAs
- Permeable peptide’ properties
Off-the-Shelf Peptide DEL
WuXi Biology provides Off-the-Shelf Peptide DEL with over 300 billion diverse peptides
Customized Peptide DEL
WuXi Biology provides customized libraries, leveraging abundant natural amino acids and their derivatives to enhance the structural optimization and modification of natural peptides and unnatural amino acids to offer far superior structural diversity than natural amino acids. There are two cyclization Strategies: one is nature-based method, and the other is chemistry-based method.
Affinity Selection of High Quality & Efficiency
1. Affinity Selection
- Multiple, parallel, customized conditions (starting from 4 conditions and up to 8 selection conditions) for specific selection needs;
- No target control as reference.
2. qPCR Quantitation
- Determining the DEL quantity & number of PCR cycles to eliminate bias;
- High accuracy;
- Monitoring recovery rate.
3. PCR
- Multiple, parallel, customized conditions (starting from 4 conditions and up to 8 selection conditions) for specific selection needs;
- No target control as reference.
2. qPCR Quantitation
- Determining the DEL quantity & number of PCR cycles to eliminate bias;
- High accuracy;
- Monitoring recovery rate.
Display to Peptide DEL for Hit-to-Lead Optimization
