Tumor Models Archives - Page 3 of 11

Developing Novel AR Mutant Prostate Cancer Models

Since prostate cancer heavily depends on androgen hormones for growth, targeting the androgen receptor (AR) signaling pathway is a key...

BTK Inhibitor-Resistant Lymphoma Animal Models

Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in Western populations. Targeted therapies, including the use...

Oncogenic Virus-associated Tumor Models

Viruses have well-established causal roles in numerous human cancers. Approximately 10% of cancers globally are attributed to viral infections, primarily...

OncoWuXi Express: Comprehensive PDX Panel Service for Drug Discovery

OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well...

USP7 Inhibitors Reveal a Differentiated Mechanism of p53-Driven Anti-Cancer Activity

Ubiquitin-speciﬁc protease 7 (USP7) is a deubiquitinating enzyme that cleaves ubiquitin from a range of substrates, shielding them from degradation...

Paclitaxel-Induced Resistant Tumor Models

Despite the excellent clinical response to paclitaxel therapy, drug resistance inevitably develops in subsequent treatments. The mechanisms for resistance to...