Tumor Models Archives - WuXi Biology

ALDH1A2 Inhibition Enhances Antitumor DC Vaccine Efficacy

Strategies to stimulate dendritic cell (DC) activity, such as ex vivo generation and priming of DC vaccines, have been explored...

KRAS G12D Inhibitor-induced Resistant Tumor Models

KRAS mutations act as primary initiators of carcinogenesis in several major cancers and are present in approximately 20 – 25%...

Radionuclide Drug Conjugates in Anticancer Treatment

Mechanisms, Recent Progress, and Animal Models Radionuclide drug conjugates (RDCs), a novel class of precision tumor-targeting therapeutic and diagnostic agents,...

DLL3‑related Tumor Models in Humanized Mice

OncoWuXi Express will continue to keep you informed about updates to our online pharmacology model database (OncoWuXi Database), as well...

Spontaneous Mouse Tumor-derived Syngeneic Models

Spontaneous mouse tumor-derived syngeneic models are valuable tools in preclinical cancer research. These tumor models offer unique advantages because immunotherapies...

PBMC Humanized Tumor Models for Evaluating T-cell Engagers

T-cell engagers (TCEs) are a class of bispecific antibody-based immunotherapies designed to bring T cells into close proximity with cancer...

ADC Development: Preclinical Pharmacology Essentials

Antibody-drug conjugates (ADCs) are increasingly demonstrating their value in cancer treatment, especially in combination therapies and for targeting resistant cancer...

Severe Hyperglycemia and Hyperlipidemia Alter Tumor Growth and Immune Profiles in Syngeneic Tumor Models

Studies have demonstrated that obesity can promote cancer progression through mechanisms that include chronic low-grade inflammation. Previous research with diet-induced...

Development of NK Humanized Mouse Models

Natural killer (NK) cells play a crucial role in the immune system and can recognize and kill cancer cells. Research...

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