Knowledge Library

New Platform from Target-to-Hit

Resource Type: Webinar
Resource Topic: Biophysical Assays Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Screening Libraries Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays

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Enabling Technologies For Bifunctional Molecule Discovery And Characterization

Resource Type: Webinar
Resource Topic: Biochemical Assays Biophysical Assays Cell-based Assays Discovery Chemistry Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation

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Enabling Drug Discovery with Diverse Lead Generation Platforms

Resource Type: Webinar
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Fragment-Based Drug Discovery High-throughput screening (HTS) Hit Finding Hit-to-Lead in silico services Lead Optimization Mass Spectrometry-based Assays Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation

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Optimizing Drug Discovery Pipelines with Biophysical Methods

Resource Type: Webinar
Resource Topic: Antibodies Biochemical Assays Biomarkers Biophysical Assays Cell-based Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Oncology Phenotypic Assays Screening Libraries Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation

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Faster with high-speed fragment screening — Accelerate your drug discovery campaign

In the past, thousands of proteins were considered undruggable. The restricted number of chemical entities available and classical methods limited the exploration of this undevelopable area. Today, the combination of novel chemical modalities and advanced technical approaches has resulted in new clinical candidates from previously undruggable targets. To accelerate your drug discovery campaign, WuXi AppTec´s …Read More >

Resource Type: Article Blog Case Study
Resource Topic: Biochemical Assays Biophysical Assays Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Immunology Lead Optimization Small Molecules Structural Biology

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Identification of Tofacitinib, Filgotinib and Ruxolitinib on experimental Sjögren’s syndrome model in mice

Sjögren’s syndrome, which affects hundreds of millions of people worldwide, is a chronic autoimmune disorder characterized by leukocytic infiltration into the exocrine glands, such as the salivary and lacrimal glands. However, the pathological mechanism remains to be elucidated, and novel treatments are urgently needed. Over the past decade, extensive progress has been made in the …Read More >

Resource Type: Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology Lead Optimization Rare Diseases Small Molecules Structural Biology

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